plk4.L polo like kinase 4 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: plk4.L
Official Full Name: polo like kinase 4 L homeolog
Primary source: Xenbase:XB-GENE-866273
Locus tag: XELAEV_18005595mg
See related: EnsemblRapid:ENSXLAG00005003723
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: sak; plk4; plx4; PLK-4
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Genomic context

Location:: chromosome: 1L

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (68276193..68294354, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (57430312..57448496, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results provide the first steps in defining a new role for plk4 in organogenesis and implies a role in planar cell polarity, segmentation, and in recently described PLK4 mutations in human
Title: Developmental role of plk4 in Xenopus laevis and Danio rerio: implications for Seckel Syndrome.
Plx4, the Xenopus homolog of mammalian Plk4 and Drosophila Sak, induces de novo centriole formation in vivo in activated oocytes and in egg extracts, but not in immature or in vitro matured oocytes.
Title: Identification of a polo-like kinase 4-dependent pathway for de novo centriole formation.
Data show that Cep152 can be phosphorylated by Plk4 in vitro, suggesting that Cep152 acts with Plk4 to initiate centriole formation.
Title: Cep152 interacts with Plk4 and is required for centriole duplication.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within centriole replication	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within de novo centriole assembly involved in multi-ciliated epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic spindle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of centriole replication	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in deuterosome	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein kinase PLK4

Names: Serine/threonine-protein kinase Sak; polo-like kinase 4

NP_001083146.1

EC 2.7.11.21

XP_018096353.1

EC 2.7.11.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089677.1 → NP_001083146.1 serine/threonine-protein kinase PLK4

See identical proteins and their annotated locations for NP_001083146.1

Status: PROVISIONAL

Source sequence(s)

BC060363

UniProtKB/Swiss-Prot

Q6PAD2

Related

ENSXLAP00005011128.1, ENSXLAT00005011302.1

Conserved Domains (5) summary

smart00220
Location:12 → 265

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd13114
Location:566 → 677

POLO_box_Plk4_1; First (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13115
Location:678 → 785

POLO_box_Plk4_2; Second (cryptic) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd13116
Location:860 → 939

POLO_box_Plk4_3; C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak)

cd14186
Location:10 → 265

STKc_PLK4; Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

68276193..68294354 complement

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GenBank, FASTA, Sequence Viewer (Graphics)