ccn2.L cellular communication network factor 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ccn2.L
Official Full Name: cellular communication network factor 2 L homeolog
Primary source: Xenbase:XB-GENE-855558
Locus tag: XELAEV_18026966mg
See related: EnsemblRapid:ENSXLAG00005034172
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ccn2; ctgf; XCTGF; hcs24; ctgf.L; fisp12; fisp-12
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Genomic context

Location:: chromosome: 5L

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (72894120..72897969, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (62060823..62064672)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Recombinant CTGF added to embryonic mouse neural precursor cell culture increased the number of Sox-2-, GFAP-and GFAP/Nestin-positive cells, activated p44/42 signaling, and upregulated fibronectin. In human glioma cells, it induced GFAP and nestin.
Title: Connective-Tissue Growth Factor (CTGF/CCN2) Induces Astrogenesis and Fibronectin Expression of Embryonic Neural Cells In Vitro.
Data show that connective-tissue growth factor regulates signalling through the Wnt pathway, in accord with its ability to bind to the Wnt co-receptor LDL receptor-related protein 6 (LRP6).
Title: Connective-tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: connective tissue growth factor

Names: connective tissue growth factor L homeolog; connective tissue growth factor XCTGF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001088228.1 → NP_001081697.1 connective tissue growth factor precursor

See identical proteins and their annotated locations for NP_001081697.1

Status: PROVISIONAL

Source sequence(s)

BC094492

UniProtKB/TrEMBL

A0A974CVC5, O42607, Q505L5

Related

ENSXLAP00005102100.1, ENSXLAT00005104091.1

Conserved Domains (4) summary

smart00209
Location:196 → 237

TSP1; Thrombospondin type 1 repeats

smart00214
Location:97 → 156

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:24 → 76

IGFBP; Insulin-like growth factor binding protein

cl21545
Location:247 → 339

GHB_like; Glycoprotein hormone beta chain homologues

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

72894120..72897969 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)