fn1.S fibronectin 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fn1.S
Official Full Name: fibronectin 1 S homeolog
Primary source: Xenbase:XB-GENE-865084
Locus tag: XELAEV_18047294mg
See related: EnsemblRapid:ENSXLAG00005030511
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: fn1; fibronectin
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (74022723..74066903)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (67379846..67424092)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transplantation experiments demonstrate a tissue-autonomous role for DS epimerase-1 in cranial neural crest (NC) cell migration in vivo Cranial NC explant and single-cell cultures indicate a requirement of DS epimerase-1 in cell adhesion, spreading and extension of polarized cell processes on fibronectin.
Title: Musculocontractural Ehlers-Danlos syndrome and neurocristopathies: dermatan sulfate is required for Xenopus neural crest cells to migrate and adhere to fibronectin.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acute-phase response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibronectin

Names: FN; gene C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087801.1 → NP_001081270.1 fibronectin precursor

See identical proteins and their annotated locations for NP_001081270.1

Status: PROVISIONAL

Source sequence(s)

BC072841

UniProtKB/Swiss-Prot

Q91740

UniProtKB/TrEMBL

A0A974BUU9, Q6GQA5

Related

ENSXLAP00005091303.1, ENSXLAT00005092982.1

Conserved Domains (6) summary

smart00059
Location:354 → 402

FN2; Fibronectin type 2 domain

smart00058
Location:2301 → 2345

FN1; Fibronectin type 1 domain

cd00061
Location:2389 → 2428

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1724 → 1804

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00039
Location:234 → 273

fn1; Fibronectin type I domain

pfam00041
Location:1540 → 1621

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054388.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

74022723..74066903

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_041577682.1 → XP_041433616.1 fibronectin isoform X3

UniProtKB/TrEMBL

A0A8J1LX35, A0A974BUU9

Conserved Domains (5) summary

smart00059
Location:353 → 401

FN2; Fibronectin type 2 domain

smart00058
Location:2185 → 2229

FN1; Fibronectin type 1 domain

smart00060
Location:1358 → 1437

FN3; Fibronectin type 3 domain

cd00061
Location:2273 → 2312

FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...

cd00063
Location:1539 → 1621

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_018237300.2 → XP_018092789.1 fibronectin isoform X1

UniProtKB/TrEMBL

A0A8J0TYR8, A0A974BUU9

Related

ENSXLAP00005092725.1, ENSXLAT00005094408.1
XM_018237301.2 → XP_018092790.1 fibronectin isoform X2

UniProtKB/TrEMBL

A0A8J0U0C7, A0A974BUU9
XM_018237302.2 → XP_018092791.1 fibronectin isoform X4

UniProtKB/TrEMBL

A0A8J0TXE5, A0A974BUU9