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pam.S peptidylglycine alpha-amidating monooxygenase S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 397736, updated on 18-Sep-2024

Summary

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Official Symbol
pam.S
Official Full Name
peptidylglycine alpha-amidating monooxygenase S homeolog
Primary source
Xenbase:XB-GENE-6252615
Locus tag
XELAEV_18010794mg
See related
EnsemblRapid:ENSXLAG00005028517
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
pal; phm; AE-I; pamb; pam-a; pam-b
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Genomic context

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Location:
chromosome: 1S
Exon count:
27
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (163724749..163836092, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (147719628..147831267, complement)

Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121399121 Neighboring gene uncharacterized LOC121399505 Neighboring gene macrophage immunometabolism regulator S homeolog Neighboring gene solute carrier organic anion transporter family member 4C1 S homeolog Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 S homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of cDNA encoding a new peptide C-terminal alpha-amidating enzyme having a putative membrane-spanning domain from Xenopus laevis skin. Ohsuye K, et al. Biochem Biophys Res Commun, 1988 Feb 15. PMID 2829895
  2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables peptidylamidoglycolate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidylglycine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within peptide metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidyl-glycine alpha-amidating monooxygenase B
Names
AE-II
alpha-amidating enzyme
peptide C-terminal alpha-amidating enzyme II
peptidyl-glycine alpha-amidating monooxygenase II
peptidylglycine alpha-amidating monooxygenase b
NP_001081254.1
XP_018089581.1
XP_018089595.1
XP_018089603.1
XP_041429444.1
XP_041429450.1
XP_041429454.1
XP_041429461.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087785.1 → NP_001081254.1  peptidyl-glycine alpha-amidating monooxygenase B precursor

    See identical proteins and their annotated locations for NP_001081254.1

    Status: PROVISIONAL

    Source sequence(s)
    M19032
    UniProtKB/Swiss-Prot
    P12890
    UniProtKB/TrEMBL
    A0A974DX15
    Related
    ENSXLAP00005085560.1, ENSXLAT00005087222.1
    Conserved Domains (3) summary
    cd14958
    Location:400 → 707
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:61 → 171
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:199 → 345
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    163724749..163836092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041573520.1 → XP_041429454.1  peptidyl-glycine alpha-amidating monooxygenase B isoform X3

    UniProtKB/TrEMBL
    A0A8J1LK39, A0A974DX15
    Related
    ENSXLAP00005085329.1, ENSXLAT00005086992.1
    Conserved Domains (1) summary
    cd14958
    Location:507 → 814
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)

  2. XM_041573527.1 → XP_041429461.1  peptidyl-glycine alpha-amidating monooxygenase B isoform X4

    UniProtKB/TrEMBL
    A0A8J1LJJ9, A0A974DX15
    Conserved Domains (1) summary
    cd14958
    Location:484 → 791
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)

  3. XM_018234106.2 → XP_018089595.1  peptidyl-glycine alpha-amidating monooxygenase B isoform X6

    UniProtKB/TrEMBL
    A0A8J0TQN7, A0A974DX15

  4. XM_041573516.1 → XP_041429450.1  peptidyl-glycine alpha-amidating monooxygenase B isoform X2

    UniProtKB/TrEMBL
    A0A8J1LL68, A0A974DX15
    Conserved Domains (1) summary
    cd14958
    Location:506 → 813
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)

  5. XM_018234092.2 → XP_018089581.1  peptidyl-glycine alpha-amidating monooxygenase B isoform X5

    UniProtKB/TrEMBL
    A0A1L8HR43, A0A974DVF9, A0A974DX15

  6. XM_018234114.1 → XP_018089603.1  peptidyl-glycine alpha-amidating monooxygenase B isoform X1

    UniProtKB/TrEMBL
    A0A8J0TIY7, A0A974DX15
    Conserved Domains (3) summary
    cd14958
    Location:507 → 814
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:62 → 171
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:199 → 345
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

  7. XM_041573510.1 → XP_041429444.1  peptidyl-glycine alpha-amidating monooxygenase B isoform X1

    UniProtKB/TrEMBL
    A0A8J0TIY7, A0A974DX15
    Related
    ENSXLAP00005085113.1, ENSXLAT00005086775.1
    Conserved Domains (3) summary
    cd14958
    Location:507 → 814
    NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
    pfam01082
    Location:62 → 171
    Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
    pfam03712
    Location:199 → 345
    Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12890.1 GenPept UniProtKB/Swiss-Prot:P12890

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