TNFRSF1A TNF receptor superfamily member 1A [Sus scrofa (pig)] - Gene

Summary

Official Symbol: TNFRSF1Aprovided by VGNC
Official Full Name: TNF receptor superfamily member 1Aprovided by VGNC
Primary source: VGNC:VGNC:109417
See related: Ensembl:ENSSSCG00000000708
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Expression: Ubiquitous expression in lung (RPKM 60.1), spleen (RPKM 53.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	5	NC_010447.5 (64319349..64331876)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	5	NC_010447.4 (66780726..66793255)

Chromosome 5 - NC_010447.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicated that TNFRSF1A activated the TNF signaling pathway and inhibited the NFkappaB signaling pathway in vitro. These findings provide evidence for an immune-related regulatory function for porcine TNFRSF1A.
Title: Genomic variant in porcine TNFRSF1A gene and its effects on TNF signaling pathway in vitro.
Retinal ischemia results in increased expression of TNF-alpha and its receptors (TNF-R1 and TNF-R2).
Title: Tumor necrosis factor and its receptors in the neuroretina and retinal vasculature after ischemia-reperfusion injury in the pig retina.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables tumor necrosis factor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables tumor necrosis factor receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane raft	IEA Inferred from Electronic Annotation more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info	PubMed
part_of receptor complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor receptor superfamily member 1A

Names: TNF-R1; TNF-RI; TNFR-I; p55 TNF receptor; p60; tumor necrosis factor receptor 1; tumor necrosis factor receptor type I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213969.1 → NP_999134.1 tumor necrosis factor receptor superfamily member 1A precursor

See identical proteins and their annotated locations for NP_999134.1

Status: PROVISIONAL

Source sequence(s)

U19994

UniProtKB/Swiss-Prot

P50555

UniProtKB/TrEMBL

A0A0B8RVF0, A0A8D1I359, F1SL26

Related

ENSSSCP00000000755.4, ENSSSCT00000000771.5

Conserved Domains (2) summary

cd08313
Location:364 → 444

Death_TNFR1; Death domain of Tumor Necrosis Factor Receptor 1

cd10576
Location:44 → 175

TNFRSF1A; Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), also known as TNFR1