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Pdi Protein disulfide isomerase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39651, updated on 18-Sep-2024

Summary

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Official Symbol
Pdiprovided by FlyBase
Official Full Name
Protein disulfide isomeraseprovided by FlyBase
Primary source
FLYBASE:FBgn0286818
Locus tag
Dmel_CG6988
See related
AllianceGenome:FB:FBgn0286818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6988; Dmel\CG6988; dpdi; Dpdi; EP(3)1022; l(3)j2A2; pdi; PDI
Summary
Predicted to enable protein-disulfide reductase activity. Located in several cellular components, including fusome; rough endoplasmic reticulum; and spindle envelope. Is expressed in several structures, including ectoderm; embryonic/larval fat body; epidermis; extended germ band embryo; and ovariole. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to several human genes including P4HB (prolyl 4-hydroxylase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
71B5-71B5; 3-42 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15137738..15142840, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15130838..15135940, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Centrosomal protein 135kDa Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU5-U42 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45396 Neighboring gene antisense RNA:CR45397 Neighboring gene uncharacterized protein Neighboring gene Peroxin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila gene that encodes a member of the protein disulfide isomerase/phospholipase C-alpha family. McKay RR, et al. Insect Biochem Mol Biol, 1995 May. PMID 7787847
  2. Distribution of ryanodine receptor Ca(2+) channels in insect photoreceptor cells. Baumann O. J Comp Neurol, 2000 Jun 5. PMID 10813791
  3. Cloning of the alpha subunit of prolyl 4-hydroxylase from Drosophila and expression and characterization of the corresponding enzyme tetramer with some unique properties. Annunen P, et al. J Biol Chem, 1999 Mar 5. PMID 10037780
  4. The Drosophila reticulon, Rtnl-1, has multiple differentially expressed isoforms that are associated with a sub-compartment of the endoplasmic reticulum. Wakefield S, et al. Cell Mol Life Sci, 2006 Sep. PMID 16847576, Free PMC Article
  5. G-rich, a Drosophila selenoprotein, is a Golgi-resident type III membrane protein. Chen CL, et al. Biochem Biophys Res Commun, 2006 Oct 6. PMID 16920070

See all (105) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fusome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle envelope IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein disulfide isomerase
Names
CG6988-PA
CG6988-PE
Pdi-PA
Pdi-PE
disulfide isomerase
lethal (3) j2A2
proline diisomerease
protein disulphide isomerase
protein-disulfide isomerase
NP_001287070.1
NP_524079.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15137738..15142840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300141.1 → NP_001287070.1  protein disulfide isomerase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287070.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54399, Q53YH5, Q86PE2, Q8IQL8, Q9VUL7
    UniProtKB/TrEMBL
    X2JGP4
    Conserved Domains (5) summary
    cd02981
    Location:137 → 231
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02982
    Location:244 → 347
    PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:368 → 469
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    TIGR01126
    Location:33 → 133
    pdi_dom; protein disulfide-isomerase domain
    TIGR01130
    Location:27 → 474
    ER_PDI_fam; protein disulfide isomerase, eukaryotic

  2. NM_079355.3 → NP_524079.1  protein disulfide isomerase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524079.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54399, Q53YH5, Q86PE2, Q8IQL8, Q9VUL7
    UniProtKB/TrEMBL
    X2JGP4
    Related
    FBpp0075401
    Conserved Domains (5) summary
    cd02981
    Location:137 → 231
    PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02982
    Location:244 → 347
    PDI_b'_family; Protein Disulfide Isomerase (PDIb') family, redox inactive TRX-like domain b'; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
    cd02995
    Location:368 → 469
    PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
    TIGR01126
    Location:33 → 133
    pdi_dom; protein disulfide-isomerase domain
    TIGR01130
    Location:27 → 474
    ER_PDI_fam; protein disulfide isomerase, eukaryotic
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54399.1 P54399
X2JGP4 X2JGP4

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