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CG8757 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39528, updated on 10-May-2024

Summary

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Official Symbol
CG8757provided by FlyBase
Primary source
FLYBASE:FBgn0036380
Locus tag
Dmel_CG8757
See related
AllianceGenome:FB:FBgn0036380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8757; FOHSDR
Summary
Predicted to enable 17-beta-hydroxysteroid dehydrogenase (NADP+) activity; 17-beta-ketosteroid reductase activity; and 3-keto sterol reductase activity. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG8757 in Genome Data Viewer
Location:
70C4-70C4; 3-41 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13840197..13842240, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13833297..13835340, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene bruno 3 Neighboring gene mir-289 stem loop Neighboring gene antisense RNA:CR46266 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 68C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SuUR protein binds to the boundary regions separating forum domains in Drosophila melanogaster. Tchurikov NA, et al. J Biol Chem, 2004 Mar 19. PMID 14702350
  2. Methionine restriction breaks obligatory coupling of cell proliferation and death by an oncogene Src in Drosophila. Nishida H, et al. Elife, 2021 Apr 27. PMID 33902813, Free PMC Article
  3. Integrated analysis of the aging brain transcriptome and proteome in tauopathy. Mangleburg CG, et al. Mol Neurodegener, 2020 Sep 29. PMID 32993812, Free PMC Article
  4. Nuclear chromosome dynamics in the Drosophila male germ line contribute to the nonrandom genomic distribution of retrogenes. Díaz-Castillo C, et al. Mol Biol Evol, 2012 Sep. PMID 22427708
  5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 17-beta-hydroxysteroid dehydrogenase (NADP+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 17-beta-ketosteroid reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables 3-keto sterol reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8757-PB
NP_648664.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13840197..13842240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140407.2 → NP_648664.2  uncharacterized protein Dmel_CG8757 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648664.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VU92
    Conserved Domains (2) summary
    COG4221
    Location:1 → 252
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
    cl21454
    Location:1 → 247
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VU92 Q9VU92

Gene LinkOut

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