ncoa2.S nuclear receptor coactivator 2 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ncoa2.S
Official Full Name: nuclear receptor coactivator 2 S homeolog
Primary source: Xenbase:XB-GENE-864856
Locus tag: XELAEV_18033788mg
See related: EnsemblRapid:ENSXLAG00005026753
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: src2; tif2; XTIF2; grip1; ncoa2; kat13c; bhlhe75; ncoa2-A
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Genomic context

Location:: chromosome: 6S

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6S	NC_054382.1 (105787467..105880589, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6S	NC_030735.1 (97121083..97214518, complement)

Chromosome 6S - NC_054382.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables nuclear receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor coactivator activity	ISS Inferred from Sequence or Structural Similarity more info
enables nuclear thyroid hormone receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hormone stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear receptor coactivator 2

Names: NCoA-2; transcriptional intermediary factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087670.1 → NP_001081139.1 nuclear receptor coactivator 2

See identical proteins and their annotated locations for NP_001081139.1

Status: PROVISIONAL

Source sequence(s)

AJ243119

UniProtKB/Swiss-Prot

Q9W705

UniProtKB/TrEMBL

A0A974CPC1

Related

ENSXLAP00005079529.1, ENSXLAT00005081120.1

Conserved Domains (8) summary

smart00353
Location:32 → 86

HLH; helix loop helix domain

smart00091
Location:115 → 172

PAS; PAS domain

pfam07469
Location:1365 → 1421

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:1056 → 1101

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:626 → 699

SRC-1; Steroid receptor coactivator

pfam14598
Location:259 → 368

PAS_11; PAS domain

pfam16279
Location:721 → 805

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:453 → 576

NCOA_u2; Unstructured region on nuclear receptor coactivator protein

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054382.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

105787467..105880589 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018268607.2 → XP_018124096.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/TrEMBL

A0A1L8FTB0, A0A974CM76, A0A974CPC1

Related

ENSXLAP00005079817.1, ENSXLAT00005081409.1
XM_041567089.1 → XP_041423023.1 nuclear receptor coactivator 2 isoform X2

UniProtKB/TrEMBL

A0A8J1L1Z3, A0A974CPC1

Conserved Domains (9) summary

smart00091
Location:118 → 175

PAS; PAS domain

pfam09606
Location:1089 → 1380

Med15; ARC105 or Med15 subunit of Mediator complex non-fungal

cd18950
Location:28 → 91

bHLH-PAS_NCoA2_SRC2; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in nuclear receptor coactivator 2 (NCoA-2) and similar proteins

pfam07469
Location:1291 → 1348

DUF1518; Domain of unknown function (DUF1518)

pfam08815
Location:1059 → 1103

Nuc_rec_co-act; Nuclear receptor coactivator

pfam08832
Location:625 → 702

SRC-1; Steroid receptor coactivator

pfam14598
Location:262 → 371

PAS_11; PAS domain

pfam16279
Location:724 → 808

DUF4927; Domain of unknown function (DUF4927)

pfam16665
Location:456 → 579

NCOA_u2; Unstructured region on nuclear receptor coactivator protein
XM_018268606.2 → XP_018124095.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/TrEMBL

A0A1L8FTB0, A0A974CM76, A0A974CPC1
XM_018268608.2 → XP_018124097.1 nuclear receptor coactivator 2 isoform X1

UniProtKB/TrEMBL

A0A1L8FTB0, A0A974CM76, A0A974CPC1