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DEF8 differentially expressed in FDCP 8 homolog [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39381, updated on 11-Sep-2024

Summary

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Official Symbol
DEF8provided by FlyBase
Official Full Name
differentially expressed in FDCP 8 homologprovided by FlyBase
Primary source
FLYBASE:FBgn0046296
Locus tag
Dmel_CG11534
See related
AllianceGenome:FB:FBgn0046296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:GH12489; CG11534; Def8; Dmel\CG11534
Summary
Predicted to be involved in intracellular signal transduction. Is expressed in organism. Orthologous to human DEF8 (differentially expressed in FDCP 8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
68F5-68F5; 3-38 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12132146..12133834)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12125246..12126934)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR11538 Neighboring gene uncharacterized protein Neighboring gene Larval serum protein 2 Neighboring gene antisense RNA:CR45892 Neighboring gene uncharacterized protein Neighboring gene Autophagy-related 12 Neighboring gene NADH dehydrogenase (ubiquinone) SGDH subunit Neighboring gene Rho GTPase activating protein at 68F

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of novel plekhm1 and def8 mutant alleles in Drosophila. Maruzs T, et al. Biol Futur, 2022 Jun. PMID 35507305
  2. Evidence for a gene involved in multiple and diverse rearrangements in the Drosophila genus. Puerma E, et al. Mol Biol Evol, 2014 Nov. PMID 25135946
  3. Small heat shock proteins determine synapse number and neuronal activity during development. Santana E, et al. PLoS One, 2020. PMID 32437379, Free PMC Article
  4. An in vivo RNAi mini-screen in Drosophila cancer models reveals novel potential Wnt targets in liver cancer. Even İ, et al. Turk J Gastroenterol, 2019 Feb. PMID 30541713, Free PMC Article
  5. The PHD finger, a nuclear protein-interaction domain. Bienz M. Trends Biochem Sci, 2006 Jan. PMID 16297627

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
differentially expressed in FDCP 8 homolog
Names
CG11534-PA
DEF8-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12132146..12133834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140292.3 → NP_648549.1  differentially expressed in FDCP 8 homolog [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648549.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VTT9
    Related
    FBpp0075727
    Conserved Domains (2) summary
    smart00109
    Location:173 → 214
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
    pfam13901
    Location:259 → 461
    zf-RING_9; Putative zinc-RING and/or ribbon
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VTT9.1 Q9VTT9

Gene LinkOut

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Chemical Information
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