macrod2 mono-ADP ribosylhydrolase 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: macrod2provided by ZNC
Official Full Name: mono-ADP ribosylhydrolase 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1490
See related: Ensembl:ENSDARG00000032601 AllianceGenome:ZFIN:ZDB-GENE-040426-1490
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:65960
Summary: Predicted to enable ADP-ribosylglutamate hydrolase activity. Predicted to be involved in cellular response to DNA damage stimulus; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Predicted to be active in nucleoplasm. Orthologous to human MACROD2 (mono-ADP ribosylhydrolase 2). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (33703730..34560375)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (33351576..34434369)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

G41743 (e-PCR)
- UniSTS:79753

G39803 (e-PCR)
- UniSTS:78222

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ADP-ribosylglutamate hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-glutamate ADP-deribosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleoside metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ADP-ribose glycohydrolase MACROD2; O-acetyl-ADP-ribose deacetylase MACROD2

Names: MACRO domain containing 2

NP_956843.1

EC 3.2.2.-

EC 3.5.1.-

XP_017214209.1

EC 3.2.2.-

EC 3.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200549.1 → NP_956843.1 ADP-ribose glycohydrolase MACROD2

See identical proteins and their annotated locations for NP_956843.1

Status: PROVISIONAL

Source sequence(s)

BC056529

UniProtKB/TrEMBL

Q6PHJ5

Related

ENSDARP00000142403.2, ENSDART00000173361.2

Conserved Domains (2) summary

COG2110
Location:65 → 230

YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]

cd02908
Location:62 → 228

Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...