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sik3 SIK family kinase 3 [ Danio rerio (zebrafish) ]

Gene ID: 393513, updated on 27-Mar-2024

Summary

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Official Symbol
sik3provided by ZNC
Official Full Name
SIK family kinase 3provided by ZNC
Primary source
ZFIN:ZDB-GENE-140106-203
See related
AllianceGenome:ZFIN:ZDB-GENE-140106-203
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:66101; zgc:85904
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein kinase activity. Predicted to be involved in intracellular signal transduction; microtubule cytoskeleton organization; and protein phosphorylation. Predicted to act upstream of or within phosphorylation. Predicted to be active in cytoplasm. Orthologous to human SIK3 (SIK family kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See sik3 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
24
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (47501589..47578930)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (46832243..47025640, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene paired like homeobox 2A Neighboring gene inositol polyphosphate phosphatase-like 1a Neighboring gene uncharacterized LOC101884560 Neighboring gene SID1 transmembrane family, member 2 Neighboring gene uncharacterized LOC101883079 Neighboring gene transmembrane protein 25 Neighboring gene centrosomal protein 164

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. RNA structure replaces the need for U2AF2 in splicing. Lin CL, et al. Genome Res, 2016 Jan. PMID 26566657, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC66101

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tau-protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase SIK3 homolog
Names
serine/threonine-protein kinase QSK homolog
zmp:0000001243
NP_956835.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200541.1 → NP_956835.1  serine/threonine-protein kinase SIK3 homolog

    See identical proteins and their annotated locations for NP_956835.1

    Status: PROVISIONAL

    Source sequence(s)
    BC056316
    UniProtKB/Swiss-Prot
    Q6NSM8, Q6PHV1
    Conserved Domains (3) summary
    smart00220
    Location:61 → 312
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14071
    Location:60 → 312
    STKc_SIK; Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases
    cl21463
    Location:341 → 385
    UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    47501589..47578930
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NSM8.1 GenPept UniProtKB/Swiss-Prot:Q6NSM8

Gene LinkOut

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Research Materials
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