umps uridine monophosphate synthetase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: umpsprovided by ZNC
Official Full Name: uridine monophosphate synthetaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-785
See related: Ensembl:ENSDARG00000012215 AllianceGenome:ZFIN:ZDB-GENE-040426-785
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55702; zgc:55723
Summary: Predicted to enable orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Predicted to be involved in UMP biosynthetic process and pyrimidine nucleobase biosynthetic process. Predicted to act upstream of or within 'de novo' pyrimidine nucleobase biosynthetic process; nucleoside metabolic process; and pyrimidine nucleotide biosynthetic process. Is expressed in several structures, including alar plate midbrain region; central nervous system; immature eye; mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (11576502..11587070, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (11605299..11615867, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables orotate phosphoribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotate phosphoribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables orotidine-5'-phosphate decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables orotidine-5'-phosphate decarboxylase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within 'de novo' pyrimidine nucleobase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uridine 5'-monophosphate synthase

NP_956468.2

EC 4.1.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200174.2 → NP_956468.2 uridine 5'-monophosphate synthase

Status: PROVISIONAL

Source sequence(s)

CU468956

UniProtKB/TrEMBL

A0A8M1PAW5, B8JLL1

Related

ENSDARP00000035728.6, ENSDART00000030995.8

Conserved Domains (2) summary

COG0461
Location:9 → 198

PyrE; Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]

pfam00215
Location:249 → 463

OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family