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    VSIG8 V-set and immunoglobulin domain containing 8 [ Homo sapiens (human) ]

    Gene ID: 391123, updated on 9-Jun-2013
    Official Symbol
    VSIG8provided by HGNC
    Official Full Name
    V-set and immunoglobulin domain containing 8provided by HGNC
    Primary source
    HGNC:32063
    Locus tag
    RP11-190A12.5
    See related
    Ensembl:ENSG00000243284; HPRD:18404; Vega:OTTHUMG00000168834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Location :
    1q23.2
    Sequence :
    Chromosome: 1; NC_000001.10 (159824106..159832447, complement)
    See VSIG8 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene Fc receptor-like 6 Neighboring gene SLAM family member 8 Neighboring gene chromosome 1 open reading frame 204 Neighboring gene coiled-coil domain containing 19 Neighboring gene uncharacterized LOC100286989

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Charting the landscape of tandem BRCT domain-mediated protein interactions. Woods NT, et al. Sci Signal, 2012 Sep 18. PMID 22990118.
    2. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
    3. Charting the molecular network of the drug target Bcr-Abl. Brehme M, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19380743.
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:133813 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:133813 BioGRID:108374 EPS15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:133813 BioGRID:115283 USP15    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Potential readthrough

    Included gene: CCDC19

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    V-set and immunoglobulin domain-containing protein 8
    Names
    V-set and immunoglobulin domain-containing protein 8

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013661.1 → NP_001013683.1  V-set and immunoglobulin domain-containing protein 8 precursor

      Status: VALIDATED

      Source sequence(s)
      AL590560
      Consensus CDS
      CCDS30913.1
      UniProtKB/Swiss-Prot
      Q5VU13
      Related
      ENSP00000357080, OTTHUMP00000033460, ENST00000368100, OTTHUMT00000085978
      Conserved Domains (3) summary
      cd00096
      Location:163 – 253
      Blast Score: 89
      Ig; Immunoglobulin domain
      pfam07686
      Location:35 – 129
      Blast Score: 137
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:37 – 128
      Blast Score: 123
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p10 Primary Assembly

      Range
      159824106..159832447, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      131180790..131189134, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018912.1 Alternate CHM1_1.0

      Range
      166319790..166328123, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01016617.1 (318614..326958) None
    genomic AL590560.9 CAH71106.1
    genomic AMYH01001448.1 (84238..92571) None
    mRNA BC132893.1 AAI32894.1
    mRNA BC132895.1 AAI32896.1
    other-genetic HQ258612.1 ADR83364.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VU13.1 GenPept UniProtKB/Swiss-Prot:Q5VU13

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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