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CG5068 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39032, updated on 10-May-2024

Summary

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Official Symbol
CG5068provided by FlyBase
Primary source
FLYBASE:FBgn0035951
Locus tag
Dmel_CG5068
See related
AllianceGenome:FB:FBgn0035951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG5068
Summary
Enables serine hydrolase activity. Predicted to be involved in protein demethylation. Is expressed in adult head and organism. Orthologous to human PPME1 (protein phosphatase methylesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG5068 in Genome Data Viewer
Location:
66F1-66F1; 3-28 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8986710..8989135)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8979810..8982235)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Signal recognition particle 68 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Galactokinase Neighboring gene uncharacterized protein Neighboring gene smaug Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation. Daenzer JM, et al. Dis Model Mech, 2016 Nov 1. PMID 27562100, Free PMC Article
  2. Systematic determination of patterns of gene expression during Drosophila embryogenesis. Tomancak P, et al. Genome Biol, 2002. PMID 12537577, Free PMC Article
  3. Ancient Male Recombination Shaped Genetic Diversity of Neo-Y Chromosome in Drosophila albomicans. Satomura K, et al. Mol Biol Evol, 2016 Feb. PMID 26494844
  4. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
  5. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables protein methylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein methylesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in protein demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG5068-PA
CG5068-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8986710..8989135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274680.1 → NP_001261609.1  uncharacterized protein Dmel_CG5068, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R98, Q9VSS6
    Conserved Domains (2) summary
    COG0596
    Location:70 → 204
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:73 → 161
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_140020.3 → NP_648277.3  uncharacterized protein Dmel_CG5068, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648277.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R98, Q9VSS6
    Related
    FBpp0076246
    Conserved Domains (2) summary
    COG0596
    Location:70 → 204
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam12695
    Location:73 → 161
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95R98 Q95R98

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