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GstO3 Glutathione S transferase O3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38972, updated on 10-May-2024

Summary

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Official Symbol
GstO3provided by FlyBase
Official Full Name
Glutathione S transferase O3provided by FlyBase
Primary source
FLYBASE:FBgn0035904
Locus tag
Dmel_CG6776
See related
AllianceGenome:FB:FBgn0035904
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6776; Dmel\CG6776; DmGSTO3; GSTO3; T14
Summary
Enables glutathione dehydrogenase (ascorbate) activity and glutathione transferase activity. Involved in glutathione metabolic process. Predicted to be active in cytoplasm. Is expressed in adult head; adult heart; embryonic midgut chamber; and embryonic/larval midgut. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and asthma. Orthologous to human GSTO1 (glutathione S-transferase omega 1) and GSTO2 (glutathione S-transferase omega 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See GstO3 in Genome Data Viewer
Location:
66D5-66D5; 3-26 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8518885..8520295)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8511985..8513395)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Pseudouridine synthase 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sepia Neighboring gene Glutathione S transferase O2 Neighboring gene Glutathione S transferase O1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS disease models. Cha SJ, et al. Dev Cell, 2022 Mar 28. PMID 35320731
  2. Canalization by Selection of de Novo Induced Mutations. Fanti L, et al. Genetics, 2017 Aug. PMID 28576865, Free PMC Article
  3. Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the omega class glutathione S-transferases. Kim J, et al. Biochem J, 2006 Sep 15. PMID 16712527, Free PMC Article
  4. Glutathione s-transferase omega 1 activity is sufficient to suppress neurodegeneration in a Drosophila model of Parkinson disease. Kim K, et al. J Biol Chem, 2012 Feb 24. PMID 22219196, Free PMC Article
  5. Interaction of Omega, Sigma, and Theta glutathione transferases with p38b mitogen-activated protein kinase from the fruit fly, Drosophila melanogaster. Wongtrakul J, et al. J Insect Sci, 2014 May 1. PMID 25373207, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione dehydrogenase (ascorbate) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables pyrimidodiazepine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
glutathione S transferase O3
Names
CG6776-PA
GstO3-PA
glutathione transferase
NP_648234.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8518885..8520295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139977.3 → NP_648234.1  glutathione S transferase O3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648234.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VSL2
    Related
    FBpp0076348
    Conserved Domains (3) summary
    cd03184
    Location:109 → 230
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    COG0625
    Location:22 → 209
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:3 → 95
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VSL2 Q9VSL2

Gene LinkOut

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