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mtrm matrimony [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38958, updated on 18-Sep-2024

Summary

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Official Symbol
mtrmprovided by FlyBase
Official Full Name
matrimonyprovided by FlyBase
Primary source
FLYBASE:FBgn0010431
Locus tag
Dmel_CG18543
See related
AllianceGenome:FB:FBgn0010431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-D52; anonD52; CG18543; D52; Dmel\CG18543; Mtrm
Summary
Involved in meiotic chromosome segregation and regulation of meiotic cell cycle. Located in nucleus. Is expressed in nurse cell; oocyte; organism; and ovary. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
66C11-66C11; 3-24 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8413012..8414103)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8406112..8407203)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene uncharacterized protein Neighboring gene Outer segment 1 Neighboring gene Exocyst 70 Neighboring gene uncharacterized protein Neighboring gene Cbl proto-oncogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Matrimony ties Polo down: can this kinase get free? Smith SK, et al. Cell Cycle, 2008 Mar 15. PMID 18245949
  2. Functional Consequences of the Evolution of Matrimony, a Meiosis-Specific Inhibitor of Polo Kinase. Bonner AM, et al. Mol Biol Evol, 2019 Jan 1. PMID 30351378, Free PMC Article
  3. Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains. Bonner AM, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23479640, Free PMC Article
  4. Aging predisposes oocytes to meiotic nondisjunction when the cohesin subunit SMC1 is reduced. Subramanian VV, et al. PLoS Genet, 2008 Nov. PMID 19008956, Free PMC Article
  5. Regulation of Polo Kinase by Matrimony Is Required for Cohesin Maintenance during Drosophila melanogaster Female Meiosis. Bonner AM, et al. Curr Biol, 2020 Feb 24. PMID 32008903

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of Polo Kinase by Matrimony Is Required for Cohesin Maintenance during Drosophila melanogaster Female Meiosis.
    Title: Regulation of Polo Kinase by Matrimony Is Required for Cohesin Maintenance during Drosophila melanogaster Female Meiosis.
  2. We showed that Mtrm is subject to APC(Cort)-mediated proteasomal degradation and have identified a putative APC/C recognition motif in Mtrm that when mutated partially stabilized the protein in the embryo.
    Title: A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.
  3. Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.
    Title: Binding of Drosophila Polo kinase to its regulator Matrimony is noncanonical and involves two separate functional domains.
  4. In female meiosis, Mtrm regulates Polo's role in promoting nuclear envelope breakdown and the subsequent entry of the oocyte into prometaphase.
    Title: Matrimony ties Polo down: can this kinase get free?
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in distributive segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in female meiosis chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
matrimony
Names
CG18543-PA
mtrm-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8413012..8414103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139966.3 → NP_648223.1  matrimony [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648223.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B6UX71, B6UX75, B6UX76, B6UX77, B6UX82, B6UX83, B6UX94, Q23973, Q9VSJ7
    Related
    FBpp0076340
    Conserved Domains (2) summary
    smart00454
    Location:154 → 217
    SAM; Sterile alpha motif
    cl15755
    Location:162 → 210
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23973.2 Q23973

Gene LinkOut

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Chemical Information
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