U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Oseg1 Outer segment 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38957, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
Oseg1provided by FlyBase
Official Full Name
Outer segment 1provided by FlyBase
Primary source
FLYBASE:FBgn0265102
Locus tag
Dmel_CG7161
See related
AllianceGenome:FB:FBgn0265102
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7161; DAF-10; Dmel\CG7161; IFT122; mecC; OSEG; oseg1; OSEG1; OSM-4; Wdr10
Summary
Involved in intraciliary retrograde transport; non-motile cilium assembly; and positive regulation of canonical Wnt signaling pathway. Located in non-motile cilium. Is expressed in antenno-maxillary complex; chordotonal neurons; chordotonal organ precursor cell; and eo neurons. Human ortholog(s) of this gene implicated in cranioectodermal dysplasia 1. Orthologous to human IFT122 (intraflagellar transport 122). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Oseg1 in Genome Data Viewer
Location:
66C11-66C11; 3-24 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8407268..8412825, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8400368..8405925, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Jonah 66Cii Neighboring gene uncharacterized protein Neighboring gene monkey king protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene uncharacterized protein Neighboring gene Exocyst 70 Neighboring gene matrimony Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Novel tools to unravel molecular mechanisms in cilia-related disorders. Fliegauf M, et al. Trends Genet, 2006 May. PMID 16564109
  2. dTULP, the Drosophila melanogaster homolog of tubby, regulates transient receptor potential channel localization in cilia. Park J, et al. PLoS Genet, 2013. PMID 24068974, Free PMC Article
  3. An IFT-A protein is required to delimit functionally distinct zones in mechanosensory cilia. Lee E, et al. Curr Biol, 2008 Dec 23. PMID 19097904, Free PMC Article
  4. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Jékely G, et al. Bioessays, 2006 Feb. PMID 16435301
  5. New Insights into the Genetic Basis of Monge's Disease and Adaptation to High-Altitude. Stobdan T, et al. Mol Biol Evol, 2017 Dec 1. PMID 29029226, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cilium assembly ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in intraciliary retrograde transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary retrograde transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of intraciliary transport particle A IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of intraciliary transport particle A ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in non-motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
outer segment 1
Names
CG7161-PA
CG7161-PB
Oseg1-PA
Oseg1-PB
mechanosensory C

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8407268..8412825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300053.1 → NP_001286982.1  outer segment 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286982.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9D3, Q9VSJ6
    Conserved Domains (4) summary
    COG2319
    Location:8 → 307
    WD40; WD40 repeat [General function prediction only]
    TIGR00540
    Location:598 → 789
    TPR_hemY_coli; heme biosynthesis-associated TPR protein
    sd00039
    Location:25 → 59
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:22 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_139964.3 → NP_648221.3  outer segment 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648221.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9D3, Q9VSJ6
    Related
    FBpp0076386
    Conserved Domains (4) summary
    COG2319
    Location:8 → 307
    WD40; WD40 repeat [General function prediction only]
    TIGR00540
    Location:598 → 789
    TPR_hemY_coli; heme biosynthesis-associated TPR protein
    sd00039
    Location:25 → 59
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:22 → 296
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T9D3 Q8T9D3
Q9VSJ6 Q9VSJ6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous