tph1.L tryptophan hydroxylase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tph1.L
Official Full Name: tryptophan hydroxylase 1 L homeolog
Primary source: Xenbase:XB-GENE-996927
Locus tag: XELAEV_18021665mg
See related: EnsemblRapid:ENSXLAG00005019012
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: tph; tph1; tph1.S
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 4L

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4L	NC_054377.1 (491782..500495, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4L	NC_030730.1 (494597..503445, complement)

Chromosome 4L - NC_054377.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 5-monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within platelet degranulation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of hemostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within serotonin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within serotonin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in neuron projection	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: tryptophan 5-hydroxylase

Names: tryptophan 5-monooxygenase; tryptophan hydroxylase 1 S homeolog

NP_001080923.1

EC 1.14.16.4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087454.1 → NP_001080923.1 tryptophan 5-hydroxylase

See identical proteins and their annotated locations for NP_001080923.1

Status: PROVISIONAL

Source sequence(s)

L20679

UniProtKB/Swiss-Prot

Q92142

UniProtKB/TrEMBL

A0A974HMY2

Related

ENSXLAP00005056086.1, ENSXLAT00005057315.1

Conserved Domains (3) summary

TIGR01270
Location:53 → 476

Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric

cd04929
Location:55 → 128

ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes

pfam00351
Location:143 → 473

Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase