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pbx3a pre-B-cell leukemia homeobox 3a [ Danio rerio (zebrafish) ]

Gene ID: 387532, updated on 11-Apr-2024

Summary

Official Symbol
pbx3aprovided by ZNC
Official Full Name
pre-B-cell leukemia homeobox 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-031218-1
See related
Ensembl:ENSDARG00000089262 AllianceGenome:ZFIN:ZDB-GENE-031218-1
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pbx3.2; si:ch73-242f23.2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Is expressed in diencephalon; hindbrain; midbrain; spinal cord; and telencephalon. Orthologous to human PBX3 (PBX homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (5302568..5394835, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (4810628..4902641, complement)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene LIM homeobox transcription factor 1, beta a Neighboring gene multivesicular body subunit 12Ba Neighboring gene MAPK associated protein 1 Neighboring gene apical junction component 1 homolog

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pre-B-cell leukemia transcription factor 3
Names
pre-B-cell leukemia transcription factor 3a

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    5302568..5394835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171737.4XP_005171794.1  pre-B-cell leukemia transcription factor 3 isoform X2

    UniProtKB/TrEMBL
    A0A8M2BJI6
    Related
    ENSDARP00000090846.4, ENSDART00000100074.5
    Conserved Domains (2) summary
    cd00086
    Location:224284
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:32222
    PBC; PBC domain
  2. XM_005171736.4XP_005171793.1  pre-B-cell leukemia transcription factor 3 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BJ04
    Conserved Domains (2) summary
    cd00086
    Location:224294
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:32222
    PBC; PBC domain