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Best2 Bestrophin 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38727, updated on 11-Sep-2024

Summary

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Official Symbol
Best2provided by FlyBase
Official Full Name
Bestrophin 2provided by FlyBase
Primary source
FLYBASE:FBgn0035696
Locus tag
Dmel_CG10173
See related
AllianceGenome:FB:FBgn0035696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10173; dbest2; dBest2; Dmel\CG10173
Summary
Predicted to enable chloride channel activity. Predicted to be involved in chloride transport. Located in peroxisome. Is expressed in several structures, including anlage in statu nascendi; embryonic hindgut; epithelium; hindgut proper primordium; and stage 5 embryo. Human ortholog(s) of this gene implicated in autosomal dominant vitreoretinochoroidopathy; bestrophinopathy; macular degeneration; retinitis pigmentosa 50; and vitelliform macular dystrophy. Orthologous to human BEST1 (bestrophin 1); BEST3 (bestrophin 3); and BEST4 (bestrophin 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
65A10-65A10; 3-16 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6245933..6256665, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6239033..6249765, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Multi drug resistance 65 Neighboring gene uncharacterized protein Neighboring gene Lactate dehydrogenase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Single Cl- channels activated by Ca2+ in Drosophila S2 cells are mediated by bestrophins. Chien LT, et al. J Gen Physiol, 2006 Sep. PMID 16940553, Free PMC Article
  2. Glial Chloride Channels in the Function of the Nervous System Across Species. Fernandez-Abascal J, et al. Adv Exp Med Biol, 2021. PMID 35138616, Free PMC Article
  3. Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Hartzell HC, et al. Physiol Rev, 2008 Apr. PMID 18391176
  4. Drosophila bestrophin-1 chloride current is dually regulated by calcium and cell volume. Chien LT, et al. J Gen Physiol, 2007 Nov. PMID 17968025, Free PMC Article
  5. Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. Tavsanli BC, et al. Genesis, 2001 Nov. PMID 11747204

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here it is reported that bestrophin2 is a component of native Calcium channel at the plasma membrane
    Title: Single Cl- channels activated by Ca2+ in Drosophila S2 cells are mediated by bestrophins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
enables chloride channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chloride transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
bestrophin 2
Names
Best2-PA
CG10173-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    6245933..6256665 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168162.2 → NP_729159.2  bestrophin 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729159.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU35, Q9VRW4
    Related
    FBpp0076718
    Conserved Domains (1) summary
    pfam01062
    Location:13 → 324
    Bestrophin; Bestrophin, RFP-TM, chloride channel
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7YU35 Q7YU35
Q9VRW4 Q9VRW4

Gene LinkOut

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