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promL prominin-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38372, updated on 10-May-2024

Summary

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Official Symbol
promLprovided by FlyBase
Official Full Name
prominin-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0026189
Locus tag
Dmel_CG7740
See related
AllianceGenome:FB:FBgn0026189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bs29e02.y1; CG7740; Dmel\CG7740; PromL
Summary
Predicted to be integral component of membrane. Is expressed in adult head; embryonic/larval brain; fat body; and spermatozoon. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12 and retinitis pigmentosa 41. Orthologous to several human genes including PROM1 (prominin 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See promL in Genome Data Viewer
Location:
63B1-63B3; 3-6 cM
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3114450..3127724, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3114450..3127724, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Cysteine-GCA 1-4 Neighboring gene Chitinase 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Methionine-CAT 2-1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45819 Neighboring gene ALG2, alpha-1,3/1,6-mannosyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The prominin-like Gene Expressed in a Subset of Dopaminergic Neurons Regulates Locomotion in Drosophila. Ryu TH, et al. Mol Cells, 2022 Sep 30. PMID 35993164, Free PMC Article
  2. Apical and lateral cell protrusions interconnect epithelial cells in live Drosophila wing imaginal discs. Demontis F, et al. Dev Dyn, 2007 Dec. PMID 17854054
  3. Drosophila Prominin-like, a homolog of CD133, interacts with ND20 to maintain mitochondrial function. Wang X, et al. Cell Biosci, 2019. PMID 31890150, Free PMC Article
  4. A mosaic of independent innovations involving eyes shut are critical for the evolutionary transition from fused to open rhabdoms. Mahato S, et al. Dev Biol, 2018 Nov 15. PMID 30243673
  5. Microvilli-derived extracellular vesicles carry Hedgehog morphogenic signals for Drosophila wing imaginal disc development. Hurbain I, et al. Curr Biol, 2022 Jan 24. PMID 34890558

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in microvillus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
prominin-like
Names
CG7740-PA
CG7740-PB
CG7740-PC
CG7740-PD
CG7740-PE
CG7740-PG
CG7740-PH
Prominin-like
promL-PA
promL-PB
promL-PC
promL-PD
promL-PE
promL-PG
promL-PH
prominin-like protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    3114450..3127724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259658.3 → NP_001246587.1  prominin-like, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246587.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDX6
    Conserved Domains (1) summary
    pfam05478
    Location:76 → 881
    Prominin; Prominin

  2. NM_167987.4 → NP_728810.1  prominin-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728810.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
    UniProtKB/TrEMBL
    M9PH44
    Related
    FBpp0072980
    Conserved Domains (1) summary
    pfam05478
    Location:76 → 881
    Prominin; Prominin

  3. NM_139513.3 → NP_647770.1  prominin-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647770.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
    UniProtKB/TrEMBL
    M9PH44
    Related
    FBpp0072981
    Conserved Domains (1) summary
    pfam05478
    Location:76 → 881
    Prominin; Prominin

  4. NM_001274424.1 → NP_001261353.1  prominin-like, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261353.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDX6
    Conserved Domains (1) summary
    pfam05478
    Location:76 → 881
    Prominin; Prominin

  5. NM_167986.1 → NP_728809.1  prominin-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728809.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
    UniProtKB/TrEMBL
    M9PH44
    Related
    FBpp0072982, FBtr0073120
    Conserved Domains (1) summary
    pfam05478
    Location:76 → 881
    Prominin; Prominin

  6. NM_001274422.1 → NP_001261351.1  prominin-like, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261351.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
    UniProtKB/TrEMBL
    M9PH44
    Conserved Domains (1) summary
    pfam05478
    Location:76 → 881
    Prominin; Prominin

  7. NM_001382193.1 → NP_001368963.1  prominin-like, isoform H [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H5V897, M9PBK6
    Conserved Domains (1) summary
    pfam05478
    Location:76 → 881
    Prominin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PBK6 M9PBK6
M9PDX6 M9PDX6
M9PH44 M9PH44
P82295.1 P82295

Gene LinkOut

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