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Dci Dodecenoyl-CoA delta-isomerase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38100, updated on 10-May-2024

Summary

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Official Symbol
Dciprovided by FlyBase
Official Full Name
Dodecenoyl-CoA delta-isomeraseprovided by FlyBase
Primary source
FLYBASE:FBgn0035169
Locus tag
Dmel_CG13890
See related
AllianceGenome:FB:FBgn0035169
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG13890; DCI; Dmel\CG13890; PEC1; PECI
Summary
Predicted to enable dodecenoyl-CoA delta-isomerase activity. Involved in defense response to Gram-negative bacterium. Predicted to be located in peroxisome. Is expressed in adult heart; embryonic Malpighian tubule; and organism. Orthologous to several human genes including CDYL2 (chromodomain Y like 2) and ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Dci in Genome Data Viewer
Location:
61D2-61D2; 3-0.5 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (851346..852673)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (851346..852673)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Gustatory receptor 61a Neighboring gene Centrosomal protein 290kDa Neighboring gene defective proboscis extension response 20 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of fatty-acid-β-oxidation-related genes extends the lifespan of Drosophila melanogaster. Lee SH, et al. Oxid Med Cell Longev, 2012. PMID 22997544, Free PMC Article
  2. The role of lipid metabolism in aging, lifespan regulation, and age-related disease. Johnson AA, et al. Aging Cell, 2019 Dec. PMID 31560163, Free PMC Article
  3. Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. Berkey CD, et al. Cell Microbiol, 2009 Mar. PMID 19046341, Free PMC Article
  4. Bioinformatic prediction of critical genes and pathways involved in longevity in Drosophila melanogaster. Li JQ, et al. Mol Genet Genomics, 2019 Dec. PMID 31327054
  5. Drosophila mRNA Localization During Later Development: Past, Present, and Future. Hughes SC, et al. Front Genet, 2019. PMID 30899273, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisome ISM
Inferred from Sequence Model
more info
 PubMed 
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Dodecenoyl-CoA delta-isomerase
Names
CG13890-PA
Dci-PA
NP_612065.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    851346..852673
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138221.2 → NP_612065.1  Dodecenoyl-CoA delta-isomerase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612065.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MR61, Q9W0M0
    Related
    FBpp0072484
    Conserved Domains (1) summary
    cd06558
    Location:9 → 197
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MR61 Q8MR61
Q9W0M0 Q9W0M0

Gene LinkOut

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