Eipr1 EARP complex and GARP complex interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eipr1provided by MGI
Official Full Name: EARP complex and GARP complex interacting protein 1provided by MGI
Primary source: MGI:MGI:1289332
See related: Ensembl:ENSMUSG00000036613 AllianceGenome:MGI:1289332
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tssc1; D12Ertd604e
Summary: Predicted to be involved in several processes, including endocytic recycling; positive regulation of intracellular transport; and regulation of insulin secretion. Predicted to be located in trans-Golgi network. Predicted to be part of EARP complex and GARP complex. Is expressed in hippocampus; liver; neural retina; and olfactory epithelium. Orthologous to human EIPR1 (EARP complex and GARP complex interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 12.6), CNS E18 (RPKM 12.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A2; 12 11.26 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (28801802..28917493)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (28751802..28867494)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Runx2 induces bone osteolysis in a TSSC1-dependent manner.
Title: Runx2 induces bone osteolysis by transcriptional suppression of TSSC1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128250 (e-PCR)
- UniSTS:211558

D12Ertd604e (e-PCR), detects polymorphism
- UniSTS:167095

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of dense core granule transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of endocytic recycling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of EARP complex	ISO Inferred from Sequence Orthology more info
part_of GARP complex	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: EARP and GARP complex-interacting protein 1

Names: EARP-interacting protein; Golgi-associated retrograde protein-interacting protein; endosome-associated recycling protein-interacting protein; protein TSSC1; tumor suppressing subtransferable candidate 1; tumor-suppressing STF cDNA 1 protein; tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001379229.1 → NP_001366158.1 EARP and GARP complex-interacting protein 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.

Source sequence(s)

AC136986, CT010449

Conserved Domains (2) summary

sd00039
Location:37 → 74

7WD40; WD40 repeat [structural motif]

cl29593
Location:35 → 273

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001379230.2 → NP_001366159.1 EARP and GARP complex-interacting protein 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.

Source sequence(s)

AC136986, CT010449

Conserved Domains (2) summary

sd00039
Location:37 → 74

7WD40; WD40 repeat [structural motif]

cl29593
Location:35 → 273

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001403164.1 → NP_001390093.1 EARP and GARP complex-interacting protein 1 isoform b

Status: VALIDATED

Source sequence(s)

AC136986, CT010449
NM_001403165.1 → NP_001390094.1 EARP and GARP complex-interacting protein 1 isoform c

Status: VALIDATED

Source sequence(s)

AC136986, CT010449
NM_201357.3 → NP_958745.2 EARP and GARP complex-interacting protein 1 isoform a

See identical proteins and their annotated locations for NP_958745.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC136986, CT010449

Consensus CDS

CCDS25855.1

UniProtKB/Swiss-Prot

E9QN80, Q8K0G5

Related

ENSMUSP00000152220.2, ENSMUST00000221877.2

Conserved Domains (3) summary

COG2319
Location:39 → 373

WD40; WD40 repeat [General function prediction only]

sd00039
Location:137 → 174

7WD40; WD40 repeat [structural motif]

cl02567
Location:135 → 373

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

28801802..28917493

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515121.5 → XP_006515184.1 EARP and GARP complex-interacting protein 1 isoform X2

Conserved Domains (2) summary

sd00039
Location:108 → 147

7WD40; WD40 repeat [structural motif]

cl29593
Location:105 → 356

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_011243879.4 → XP_011242181.1 EARP and GARP complex-interacting protein 1 isoform X3

Conserved Domains (2) summary

sd00039
Location:38 → 77

7WD40; WD40 repeat [structural motif]

cl29593
Location:35 → 286

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...