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Cdc5 Cell division cycle 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38062, updated on 10-May-2024

Summary

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Official Symbol
Cdc5provided by FlyBase
Official Full Name
Cell division cycle 5provided by FlyBase
Primary source
FLYBASE:FBgn0265574
Locus tag
Dmel_CG6905
See related
AllianceGenome:FB:FBgn0265574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cdc5; cdc5-like; Cdc5Dm; cef1; CG6905; Dmel\CG6905
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome and regulation of transcription by RNA polymerase II. Part of Prp19 complex. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Cdc5 in Genome Data Viewer
Location:
61C1-61C1; 3-0.5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (357851..361383, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (357851..361383, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Protein tyrosine phosphatase Meg Neighboring gene methuselah Neighboring gene uncharacterized protein Neighboring gene Regulator of cullins 1b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene trachealess Neighboring gene long non-coding RNA:CR45378

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. Ohi R, et al. Mol Cell Biol, 1998 Jul. PMID 9632794, Free PMC Article
  2. A TRiP RNAi screen to identify molecules necessary for Drosophila photoreceptor differentiation. Rylee J, et al. G3 (Bethesda), 2022 Nov 4. PMID 36218412, Free PMC Article
  3. MicroRNA-Dependent Control of Sensory Neuron Function Regulates Posture Behavior in Drosophila. Klann M, et al. J Neurosci, 2021 Oct 6. PMID 34417328, Free PMC Article
  4. Alcohol Causes Lasting Differential Transcription in Drosophila Mushroom Body Neurons. Petruccelli E, et al. Genetics, 2020 May. PMID 32132098, Free PMC Article
  5. dCas9-targeted locus-specific protein isolation method identifies histone gene regulators. Tsui C, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507191, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Prp19 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Prp19 complex IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome HDA PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle 5
Names
CG6905-PA
CG6905-PB
Cdc5-PA
Cdc5-PB
cdc5
cdc5-like
cell division cycle 5 ortholog

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    357851..361383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138189.3 → NP_612033.1  cell division cycle 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612033.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RL1, Q9W0R0
    Related
    FBpp0072468
    Conserved Domains (4) summary
    smart00717
    Location:8 → 56
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11659
    Location:56 → 108
    SANT_CDC5_II; SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
    pfam11831
    Location:397 → 648
    Myb_Cef; pre-mRNA splicing factor component
    pfam13921
    Location:11 → 71
    Myb_DNA-bind_6; Myb-like DNA-binding domain

  2. NM_001169842.2 → NP_001163313.1  cell division cycle 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163313.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RL1, Q9W0R0
    Conserved Domains (4) summary
    smart00717
    Location:8 → 56
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd11659
    Location:56 → 108
    SANT_CDC5_II; SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
    pfam11831
    Location:397 → 648
    Myb_Cef; pre-mRNA splicing factor component
    pfam13921
    Location:11 → 71
    Myb_DNA-bind_6; Myb-like DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9W0R0 Q9W0R0

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