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CG8654 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37275, updated on 18-Sep-2024

Summary

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Official Symbol
CG8654provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034479
Locus tag
Dmel_CG8654
See related
AllianceGenome:FB:FBgn0034479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG8654
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be integral component of membrane. Is expressed in several structures, including ectoderm anlage; embryonic anal pad; extended germ band embryo; germ layer; and stage 5 embryo. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A12 (solute carrier family 22 member 12); SLC22A13 (solute carrier family 22 member 13); and SLC22A16 (solute carrier family 22 member 16). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
56F4-56F4; 2-90 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19979242..19984895)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15866747..15872400)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Arginine-CCT 1-2 Neighboring gene transfer RNA:Arginine-CCT 1-3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evaluation of the role of functional constraints on the integrity of an ultraconserved region in the genus Drosophila. Díaz-Castillo C, et al. PLoS Genet, 2012 Feb. PMID 22319453, Free PMC Article
  2. Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters. Eraly SA, et al. Physiol Genomics, 2004 Jun 17. PMID 15054140
  3. Drosophila SLC22 Orthologs Related to OATs, OCTs, and OCTNs Regulate Development and Responsiveness to Oxidative Stress. Engelhart DC, et al. Int J Mol Sci, 2020 Mar 15. PMID 32183456, Free PMC Article
  4. Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? Foley BR, et al. Biol Lett, 2010 Feb 23. PMID 19692395, Free PMC Article
  5. Genes encoding novel secreted and transmembrane proteins are temporally and spatially regulated during Drosophila melanogaster embryogenesis. Zúñiga A, et al. BMC Biol, 2009 Sep 22. PMID 19772636, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8654-PA
CG8654-PB
CG8654-PC
CG8654-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19979242..19984895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259513.2 → NP_001246442.1  uncharacterized protein Dmel_CG8654, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246442.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3M6
    Conserved Domains (2) summary
    cd06174
    Location:87 → 477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00879
    Location:85 → 487
    SP; MFS transporter, sugar porter (SP) family

  2. NM_001299695.1 → NP_001286624.1  uncharacterized protein Dmel_CG8654, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286624.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3M6
    Conserved Domains (2) summary
    cd06174
    Location:87 → 477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00879
    Location:85 → 487
    SP; MFS transporter, sugar porter (SP) family

  3. NM_137607.5 → NP_611451.1  uncharacterized protein Dmel_CG8654, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611451.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3M6
    Related
    FBpp0085642
    Conserved Domains (2) summary
    cd06174
    Location:87 → 477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00879
    Location:85 → 487
    SP; MFS transporter, sugar porter (SP) family

  4. NM_001259512.2 → NP_001246441.1  uncharacterized protein Dmel_CG8654, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246441.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K3M6
    Conserved Domains (2) summary
    cd06174
    Location:87 → 477
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00879
    Location:85 → 487
    SP; MFS transporter, sugar porter (SP) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3M6 Q7K3M6

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