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CG7137 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37204, updated on 10-May-2024

Summary

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Official Symbol
CG7137provided by FlyBase
Primary source
FLYBASE:FBgn0034422
Locus tag
Dmel_CG7137
See related
AllianceGenome:FB:FBgn0034422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG7137
Summary
Predicted to enable methylated histone binding activity. Predicted to be involved in cellular response to glucose starvation; rDNA heterochromatin assembly; and regulation of transcription by glucose. Predicted to be part of chromatin silencing complex. Predicted to be active in nucleolus and rDNA heterochromatin. Is expressed in adult head. Orthologous to human RRP8 (ribosomal RNA processing 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
56C4-56C4; 2-88 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (19227344..19228613)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (15114849..15116118)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene happyhour Neighboring gene coracle Neighboring gene windbeutel

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ribbon encodes a novel BTB/POZ protein required for directed cell migration in Drosophila melanogaster. Bradley PL, et al. Development, 2001 Aug. PMID 11532922
  2. Genetic and behavioral analysis of natural variation in Drosophila melanogaster pupation position. Riedl CA, et al. Fly (Austin), 2007 Jan-Feb. PMID 18690058
  3. Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease. Kim YW, et al. Alzheimers Dement, 2021 May. PMID 33576571, Free PMC Article
  4. The soluble proteome of the Drosophila antenna. Anholt RR, et al. Chem Senses, 2010 Jan. PMID 19917591, Free PMC Article
  5. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA (adenine) methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rDNA heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rDNA heterochromatin formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by glucose IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin silencing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin silencing complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of rDNA heterochromatin ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG7137-PA
gene 3
NP_611400.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    19227344..19228613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137556.4 → NP_611400.1  uncharacterized protein Dmel_CG7137 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611400.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K2B0
    Related
    FBpp0085693
    Conserved Domains (1) summary
    cl17173
    Location:150 → 358
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K2B0.1 Q7K2B0

Gene LinkOut

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