U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnaaf3 Dynein axonemal assembly factor 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37125, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
Dnaaf3provided by FlyBase
Official Full Name
Dynein axonemal assembly factor 3provided by FlyBase
Primary source
FLYBASE:FBgn0034352
Locus tag
Dmel_CG17669
See related
AllianceGenome:FB:FBgn0034352
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17669; Dmel\CG17669
Summary
Predicted to be involved in axonemal dynein complex assembly and motile cilium assembly. Predicted to be located in dynein axonemal particle. Is expressed in chordotonal neurons and spermatogonium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 2. Orthologous to human DNAAF3 (dynein axonemal assembly factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Dnaaf3 in Genome Data Viewer
Location:
55C9-55C9; 2-85 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18452737..18454462, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14340242..14341967, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene uncharacterized protein Neighboring gene Pre-RNA processing factor 19 Neighboring gene roswell Neighboring gene uncharacterized protein Neighboring gene Glutathione S transferase E11

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The Drosophila orthologue of the primary ciliary dyskinesia-associated gene, DNAAF3, is required for axonemal dynein assembly. Zur Lage P, et al. Biol Open, 2021 Oct 15. PMID 34553759, Free PMC Article
  2. The dynamics of protein localisation to restricted zones within Drosophila mechanosensory cilia. Xiang W, et al. Sci Rep, 2022 Aug 3. PMID 35922464, Free PMC Article
  3. Survey of the Ciliary Motility Machinery of Drosophila Sperm and Ciliated Mechanosensory Neurons Reveals Unexpected Cell-Type Specific Variations: A Model for Motile Ciliopathies. Zur Lage P, et al. Front Genet, 2019. PMID 30774648, Free PMC Article
  4. Drosophila auditory organ genes and genetic hearing defects. Senthilan PR, et al. Cell, 2012 Aug 31. PMID 22939627
  5. The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs. Jones CI, et al. RNA Biol, 2013 Aug. PMID 23792537, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in axonemal dynein complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axonemal dynein complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in axonemal dynein complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dynein axonemal particle ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
dynein axonemal assembly factor 3
Names
CG17669-PA
Dnaaf3-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18452737..18454462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137492.2 → NP_611336.1  dynein axonemal assembly factor 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611336.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZB91, B6IDP0, Q5U0U7
    Related
    FBpp0085901
    Conserved Domains (3) summary
    pfam14737
    Location:46 → 124
    DUF4470; Domain of unknown function (DUF4470)
    pfam14740
    Location:156 → 451
    DUF4471; Domain of unknown function (DUF4471)
    cl00388
    Location:472 → 522
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZB91.1 A1ZB91

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools