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CG10916 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37081, updated on 18-Sep-2024

Summary

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Official Symbol
CG10916provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034312
Locus tag
Dmel_CG10916
See related
AllianceGenome:FB:FBgn0034312
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG10916
Summary
Predicted to enable ubiquitin protein ligase activity and zinc ion binding activity. Involved in determination of adult lifespan. Is expressed in embryonic/larval midgut and wing disc. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
55B11-55B12; 2-84 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18173669..18175725)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14061174..14063230)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dgp-1 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene mir-11182 stem loop Neighboring gene no poles Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Antagonistic pleiotropy and mutation accumulation contribute to age-related decline in stress response. Everman ER, et al. Evolution, 2018 Feb. PMID 29214647
  2. alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila. Von Stetina JR, et al. Development, 2008 Nov. PMID 18927152, Free PMC Article
  3. no poles encodes a predicted E3 ubiquitin ligase required for early embryonic development of Drosophila. Merkle JA, et al. Development, 2009 Feb. PMID 19141674, Free PMC Article
  4. Environmental complexity and the purging of deleterious alleles. Singh A, et al. Evolution, 2017 Nov. PMID 28840604
  5. Broad RNA interference-mediated antiviral immunity and virus-specific inducible responses in Drosophila. Kemp C, et al. J Immunol, 2013 Jan 15. PMID 23255357, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG10916-PA
CG10916-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18173669..18175725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274141.2 → NP_001261070.1  uncharacterized protein Dmel_CG10916, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261070.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1R6
    Conserved Domains (4) summary
    smart00696
    Location:186 → 254
    DM9; Repeats found in Drosophila proteins
    pfam11901
    Location:133 → 246
    DUF3421; Protein of unknown function (DUF3421)
    pfam12678
    Location:32 → 74
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:32 → 74
    zf-RING_2; Ring finger domain

  2. NM_137459.3 → NP_611303.1  uncharacterized protein Dmel_CG10916, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611303.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K1R6
    Related
    FBpp0085928
    Conserved Domains (4) summary
    smart00696
    Location:186 → 254
    DM9; Repeats found in Drosophila proteins
    pfam11901
    Location:133 → 246
    DUF3421; Protein of unknown function (DUF3421)
    pfam12678
    Location:32 → 74
    zf-rbx1; RING-H2 zinc finger
    pfam13639
    Location:32 → 74
    zf-RING_2; Ring finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K1R6 Q7K1R6

Gene LinkOut

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