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fab1 fab1 kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37033, updated on 10-May-2024

Summary

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Official Symbol
fab1provided by FlyBase
Official Full Name
fab1 kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0028741
Locus tag
Dmel_CG6355
See related
AllianceGenome:FB:FBgn0028741
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6355; Dmel\CG6355; EG:52C10.5; fab-1; Fab1; l(2)SJB; PI3P5K; PIKfyve; PtdIns3P
Summary
Enables 1-phosphatidylinositol-3-phosphate 5-kinase activity. Involved in autophagosome maturation; endosome to lysosome transport; and phosphatidylinositol phosphate biosynthetic process. Located in endosome. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in Fleck corneal dystrophy. Orthologous to human PIKFYVE (phosphoinositide kinase, FYVE-type zinc finger containing). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See fab1 in Genome Data Viewer
Location:
54E9-54E9; 2-84 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17773964..17781930, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13661469..13669435, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-31a stem loop Neighboring gene adrift Neighboring gene Ubiquitin conjugating enzyme 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The localisation of PtdIns3P in Drosophila fat responds to nutrients but not insulin: a role for Class III but not Class II phosphoinositide 3-kinases. Powis KV, et al. Cell Signal, 2011 Jul. PMID 21385607
  2. ESCRTs and Fab1 regulate distinct steps of autophagy. Rusten TE, et al. Curr Biol, 2007 Oct 23. PMID 17935992
  3. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. Tian X, et al. PLoS Biol, 2015 Mar. PMID 25811491, Free PMC Article
  4. A dPIP5K dependent pool of phosphatidylinositol 4,5 bisphosphate (PIP2) is required for G-protein coupled signal transduction in Drosophila photoreceptors. Chakrabarti P, et al. PLoS Genet, 2015 Jan. PMID 25633995, Free PMC Article
  5. Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages. Edwards-Jorquera SS, et al. J Cell Biol, 2020 Mar 2. PMID 31940424, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fab1, despite its importance for endosomal functions, is not required for receptor silencing.
    Title: Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables 1-phosphatidylinositol-5-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosome to lysosome transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
fab1 kinase
Names
CG6355-PA
CG6355-PB
PtdIns(3)P 5-kinase
fab1-PA
fab1-PB
NP_611269.1
NP_995880.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17773964..17781930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137425.4 → NP_611269.1  fab1 kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611269.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZM3, O96838, Q8SZX0, Q95SX9, Q9V886
    UniProtKB/TrEMBL
    C7LAB6
    Related
    FBpp0088523
    Conserved Domains (4) summary
    smart00049
    Location:329 → 397
    DEP; Domain found in Dishevelled, Egl-10, and Pleckstrin
    cd03334
    Location:464 → 717
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd15725
    Location:182 → 243
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl02572
    Location:1413 → 1797
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...

  2. NM_206158.3 → NP_995880.1  fab1 kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995880.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZM3, O96838, Q8SZX0, Q95SX9, Q9V886
    UniProtKB/TrEMBL
    C7LAB6
    Conserved Domains (4) summary
    smart00049
    Location:329 → 397
    DEP; Domain found in Dishevelled, Egl-10, and Pleckstrin
    cd03334
    Location:464 → 717
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cd15725
    Location:182 → 243
    FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    cl02572
    Location:1413 → 1797
    PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O96838.2 O96838

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