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CG6805 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36911, updated on 18-Sep-2024

Summary

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Official Symbol
CG6805provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034179
Locus tag
Dmel_CG6805
See related
AllianceGenome:FB:FBgn0034179
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:CK01299; CK01299; Dmel\CG6805; IPP
Summary
Predicted to enable phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Predicted to be involved in inositol phosphate dephosphorylation; phosphatidylinositol dephosphorylation; and positive regulation of flagellated sperm motility. Predicted to be active in several cellular components, including neuronal cell body; non-motile cilium; and ruffle. Is expressed in several structures, including adult head; gastrula embryo; plasmatocyte primordium; and pole plasm. Human ortholog(s) of this gene implicated in congenital muscular dystrophy with cataracts and intellectual disability. Orthologous to several human genes including INPP5K (inositol polyphosphate-5-phosphatase K). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
53E4-53E4; 2-81 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17005451..17007501)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12892956..12895006)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene prenyl protease type I Neighboring gene Asparaginyl-tRNA synthetase, mitochondrial Neighboring gene Nuclear inhibitor of Protein phosphatase 1 Neighboring gene Eps15 homology domain containing protein-binding protein 1 Neighboring gene Poly(A) binding protein interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. knot is required for the hypopharyngeal lobe and its derivatives in the Drosophila embryo. Seecoomar M, et al. Mech Dev, 2000 Mar 1. PMID 10704845
  2. B.2.16 is a non-lethal modifier of the Dark(82) mosaic eye phenotype in Drosophila melanogaster. Vrailas-Mortimer AD, et al. MicroPubl Biol, 2021 Jan 18. PMID 33474526, Free PMC Article
  3. Population genomics of Wolbachia and mtDNA in Drosophila simulans from California. Signor S. Sci Rep, 2017 Oct 17. PMID 29042606, Free PMC Article
  4. A molecular basis for inositol polyphosphate synthesis in Drosophila melanogaster. Seeds AM, et al. J Biol Chem, 2004 Nov 5. PMID 15322119
  5. Xbp1-independent Ire1 signaling is required for photoreceptor differentiation and rhabdomere morphogenesis in Drosophila. Coelho DS, et al. Cell Rep, 2013 Nov 14. PMID 24183663, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ruffle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6805-PA
CG6805-PB
NP_001246379.1
NP_611178.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    17005451..17007501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_137334.4 → NP_611178.1  uncharacterized protein Dmel_CG6805, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611178.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K161
    Related
    FBpp0086120
    Conserved Domains (1) summary
    cl00490
    Location:12 → 308
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_001259450.2 → NP_001246379.1  uncharacterized protein Dmel_CG6805, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246379.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7D8
    Conserved Domains (1) summary
    cl00490
    Location:12 → 308
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7D8 A0A0B4K7D8
Q7K161 Q7K161

Gene LinkOut

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