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cars1 cysteinyl-tRNA synthetase 1 [ Danio rerio (zebrafish) ]

Gene ID: 368284, updated on 12-Sep-2024

Summary

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Official Symbol
cars1provided by ZNC
Official Full Name
cysteinyl-tRNA synthetase 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030328-29
See related
Ensembl:ENSDARG00000036164 AllianceGenome:ZFIN:ZDB-GENE-030328-29
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cars; sb:cb71
Summary
Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to act upstream of or within tRNA aminoacylation for protein translation. Predicted to be active in cytoplasm. Is expressed in several structures, including eye; hatching gland; pectoral fin musculature; polster; and tail bud. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 7
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (31796234..31830985, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (31525084..31559893, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene uncharacterized LOC137496176 Neighboring gene nucleosome assembly protein 1-like 4b Neighboring gene myosin binding protein C3 Neighboring gene lin-7 homolog C (C. elegans)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of the Beckwith-Wiedemann syndrome region in vertebrates. Paulsen M, et al. Genome Res, 2005 Jan. PMID 15590939, Free PMC Article
  2. Point mutations in KAL1 and the mitochondrial gene MT-tRNA(cys) synergize to produce Kallmann syndrome phenotype. Wang F, et al. Sci Rep, 2015 Aug 17. PMID 26278626, Free PMC Article
  3. Expression of nucleosome assembly protein 1 like genes in zebrafish embryos. Sun S, et al. Gene Expr Patterns, 2020 Jan. PMID 31669493
  4. A single Danio rerio hars gene encodes both cytoplasmic and mitochondrial histidyl-tRNA synthetases. Waldron AL, et al. PLoS One, 2017. PMID 28934368, Free PMC Article
  5. Identification of nodal signaling targets by array analysis of induced complex probes. Dickmeis T, et al. Dev Dyn, 2001 Dec. PMID 11748827

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cysteinyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cysteinyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cysteine--tRNA ligase, cytoplasmic
NP_001112372.1
XP_005168916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001118900.1 → NP_001112372.1  cysteine--tRNA ligase, cytoplasmic

    Status: PROVISIONAL

    Source sequence(s)
    AL935207
    UniProtKB/TrEMBL
    A0A8M1NI72, E7FDV9
    Related
    ENSDARP00000052513.6, ENSDART00000052514.8
    Conserved Domains (3) summary
    cd00672
    Location:108 → 523
    CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
    cd10310
    Location:2 → 74
    GST_C_CysRS_N; Glutathione S-transferase C-terminal-like, alpha helical domain of Cysteinyl-tRNA synthetase from higher eukaryotes
    PTZ00399
    Location:85 → 822
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    31796234..31830985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005168859.5 → XP_005168916.1  cysteine--tRNA ligase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8M2BGP2, E7FGP2
    Related
    ENSDARP00000112444.2, ENSDART00000129720.5
    Conserved Domains (2) summary
    cd00672
    Location:29 → 444
    CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
    PTZ00399
    Location:7 → 743
    PTZ00399; cysteinyl-tRNA-synthetase; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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