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Cabp4 calcium binding protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 365394, updated on 17-Aug-2024

Summary

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Official Symbol
Cabp4provided by RGD
Official Full Name
calcium binding protein 4provided by RGD
Primary source
RGD:1306083
See related
EnsemblRapid:ENSRNOG00000022044 AllianceGenome:RGD:1306083
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane transporter binding activity. Predicted to be involved in visual perception. Predicted to act upstream of or within neuron differentiation and phototransduction. Predicted to be located in cytosol. Orthologous to human CABP4 (calcium binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 71.2), Thymus (RPKM 14.0) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1q43
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210857223..210872431, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201428671..201442950, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219383452..219388009, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, membrane-associated 1 Neighboring gene aryl-hydrocarbon receptor-interacting protein Neighboring gene transmembrane protein 134 Neighboring gene G protein-coupled receptor 152 Neighboring gene ribosomal protein L35A, pseudogene 6 Neighboring gene coronin 1B Neighboring gene protein tyrosine phosphatase, receptor type, C-associated protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in CABP4, the gene encoding the Ca2+-binding protein 4, cause autosomal recessive night blindness. Zeitz C, et al. Am J Hum Genet, 2006 Oct. PMID 16960802, Free PMC Article
  2. Characterization of C-terminal Splice Variants of Cav1.4 Ca2+ Channels in Human Retina. Haeseleer F, et al. J Biol Chem, 2016 Jul 22. PMID 27226626, Free PMC Article
  3. A critical role of CaBP4 in the cone synapse. Maeda T, et al. Invest Ophthalmol Vis Sci, 2005 Nov. PMID 16249514, Free PMC Article
  4. Essential role of Ca2+-binding protein 4, a Cav1.4 channel regulator, in photoreceptor synaptic function. Haeseleer F, et al. Nat Neurosci, 2004 Oct. PMID 15452577, Free PMC Article
  5. The diversity of calcium sensor proteins in the regulation of neuronal function. McCue HV, et al. Cold Spring Harb Perspect Biol, 2010 Aug. PMID 20668007, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within photoreceptor cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phototransduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinal bipolar neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinal cone cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in visual perception IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
calcium-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108926.1 → NP_001102396.1  calcium-binding protein 4

    See identical proteins and their annotated locations for NP_001102396.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473953
    UniProtKB/TrEMBL
    A6HYU1, D3ZY59
    Related
    ENSRNOP00000001550.3, ENSRNOT00000001550.5
    Conserved Domains (1) summary
    PTZ00184
    Location:133 → 268
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210857223..210872431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269824.1 → XP_063125894.1  calcium-binding protein 4 isoform X3

  2. XM_039085454.2 → XP_038941382.1  calcium-binding protein 4 isoform X2

    Conserved Domains (1) summary
    PTZ00184
    Location:47 → 176
    PTZ00184; calmodulin; Provisional

  3. XM_039085440.2 → XP_038941368.1  calcium-binding protein 4 isoform X1

    Conserved Domains (1) summary
    PTZ00184
    Location:133 → 262
    PTZ00184; calmodulin; Provisional
Nucleotide Protein Strain
Heading Accession and Version

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