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Wdr12 WD repeat domain 12 [ Rattus norvegicus (Norway rat) ]

Gene ID: 363237, updated on 17-Aug-2024

Summary

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Official Symbol
Wdr12provided by RGD
Official Full Name
WD repeat domain 12provided by RGD
Primary source
RGD:735072
See related
EnsemblRapid:ENSRNOG00000017340 AllianceGenome:RGD:735072
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ribonucleoprotein complex binding activity. Predicted to be involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and regulation of cell cycle. Predicted to act upstream of or within Notch signaling pathway. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of PeBoW complex and preribosome, large subunit precursor. Orthologous to human WDR12 (WD repeat domain 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 121.5), Brain (RPKM 112.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wdr12 in Genome Data Viewer
Location:
9q32
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (68969547..68996811, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (61475498..61502762, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (66851499..66878534, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 117, member B Neighboring gene uncharacterized LOC120094801 Neighboring gene islet cell autoantigen 1-like Neighboring gene calcium responsive transcription factor Neighboring gene basic proline-rich protein-like Neighboring gene neurobeachin-like 1 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function. Moilanen AM, et al. PLoS One, 2015. PMID 25915632, Free PMC Article
  2. Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain. Nal B, et al. Genomics, 2002 Jan. PMID 11827460
  3. Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit. Rohrmoser M, et al. Mol Cell Biol, 2007 May. PMID 17353269, Free PMC Article
  4. Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex. Grimm T, et al. Nucleic Acids Res, 2006. PMID 16738141, Free PMC Article
  5. Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation. Hölzel M, et al. J Cell Biol, 2005 Aug 1. PMID 16043514, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR12 triggers distinct deterioration of cardiac function in adult rat heart.
    Title: WDR12, a Member of Nucleolar PeBoW-Complex, Is Up-Regulated in Failing Hearts and Causes Deterioration of Cardiac Function.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ribonucleoprotein complex binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISO
Inferred from Sequence Orthology
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of PeBoW complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PeBoW complex ISO
Inferred from Sequence Orthology
more info
  
part_of PeBoW complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, large subunit precursor IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor ISO
Inferred from Sequence Orthology
more info
  
part_of preribosome, large subunit precursor ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ribosome biogenesis protein WDR12
Names
WD repeat-containing protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393868.1 → NP_001380797.1  ribosome biogenesis protein WDR12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P61480
    UniProtKB/TrEMBL
    A0A8I5ZKS8, A6IPC1
    Conserved Domains (3) summary
    cd00200
    Location:100 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:145 → 187
    7WD40; WD40 repeat [structural motif]
    pfam08154
    Location:4 → 70
    NLE; NLE (NUC135) domain

  2. NM_001393869.1 → NP_001380798.1  ribosome biogenesis protein WDR12

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P61480
    UniProtKB/TrEMBL
    A0A8I5ZKS8, A6IPC1
    Related
    ENSRNOP00000078380.1, ENSRNOT00000111689.2
    Conserved Domains (3) summary
    cd00200
    Location:100 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:145 → 187
    7WD40; WD40 repeat [structural motif]
    pfam08154
    Location:4 → 70
    NLE; NLE (NUC135) domain

  3. NM_199410.3 → NP_955442.1  ribosome biogenesis protein WDR12

    See identical proteins and their annotated locations for NP_955442.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P61480
    UniProtKB/TrEMBL
    A0A8I5ZKS8, A6IPC1
    Related
    ENSRNOP00000023463.3, ENSRNOT00000023463.7
    Conserved Domains (3) summary
    cd00200
    Location:100 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:145 → 187
    7WD40; WD40 repeat [structural motif]
    pfam08154
    Location:4 → 70
    NLE; NLE (NUC135) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    68969547..68996811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596520.3 → XP_017452009.1  ribosome biogenesis protein WDR12 isoform X1

    UniProtKB/Swiss-Prot
    P61480
    UniProtKB/TrEMBL
    A0A8I5ZKS8, A6IPC1
    Conserved Domains (3) summary
    cd00200
    Location:100 → 409
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:145 → 187
    7WD40; WD40 repeat [structural motif]
    pfam08154
    Location:4 → 70
    NLE; NLE (NUC135) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61480.1 GenPept UniProtKB/Swiss-Prot:P61480

Gene LinkOut

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