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Tbc1d7 TBC1 domain family, member 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361227, updated on 18-Sep-2024

Summary

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Official Symbol
Tbc1d7provided by RGD
Official Full Name
TBC1 domain family, member 7provided by RGD
Primary source
RGD:1307661
See related
EnsemblRapid:ENSRNOG00000014019 AllianceGenome:RGD:1307661
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of TOR signaling; and negative regulation of cilium assembly. Predicted to be located in ciliary basal body and cytoplasmic vesicle. Orthologous to human TBC1D7 (TBC1 domain family member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 31.1), Brain (RPKM 29.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tbc1d7 in Genome Data Viewer
Location:
17p14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (21736898..21754499)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (21530709..21548556)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (23774793..23792389, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 1 Neighboring gene uncharacterized LOC102547830 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene uncharacterized LOC134482703 Neighboring gene phosphatase and actin regulator 1 Neighboring gene uncharacterized LOC134482770

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Regulation of mTORC1 by PI3K signaling. Dibble CC, et al. Trends Cell Biol, 2015 Sep. PMID 26159692, Free PMC Article
  2. Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complex. Nakashima A, et al. Biochem Biophys Res Commun, 2007 Sep 14. PMID 17658474
  3. TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1. Dibble CC, et al. Mol Cell, 2012 Aug 24. PMID 22795129, Free PMC Article
  4. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables TSC1-TSC2 complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in response to growth factor ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TSC1-TSC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TSC1-TSC2 complex ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
TBC1 domain family member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108411.1 → NP_001101881.1  TBC1 domain family member 7

    See identical proteins and their annotated locations for NP_001101881.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473977
    UniProtKB/TrEMBL
    A0A8I5ZX17, A6J751
    Conserved Domains (1) summary
    cl02495
    Location:147 → 247
    RabGAP-TBC; Rab-GTPase-TBC domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    21736898..21754499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276577.1 → XP_063132647.1  TBC1 domain family member 7 isoform X8

  2. XM_039095869.2 → XP_038951797.1  TBC1 domain family member 7 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZX17
    Related
    ENSRNOP00000108977.1, ENSRNOT00000143207.1
    Conserved Domains (1) summary
    cl02495
    Location:166 → 272
    RabGAP-TBC; Rab-GTPase-TBC domain

  3. XM_063276572.1 → XP_063132642.1  TBC1 domain family member 7 isoform X4

  4. XM_063276573.1 → XP_063132643.1  TBC1 domain family member 7 isoform X5

  5. XM_006253831.5 → XP_006253893.1  TBC1 domain family member 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZX17
    Related
    ENSRNOP00000019089.4, ENSRNOT00000019089.8
    Conserved Domains (1) summary
    cl02495
    Location:120 → 220
    RabGAP-TBC; Rab-GTPase-TBC domain

  6. XM_063276576.1 → XP_063132646.1  TBC1 domain family member 7 isoform X7

  7. XM_063276575.1 → XP_063132645.1  TBC1 domain family member 7 isoform X6

  8. XM_063276578.1 → XP_063132648.1  TBC1 domain family member 7 isoform X9

  9. XM_006253830.5 → XP_006253892.1  TBC1 domain family member 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZX17, D4AAY4
    Related
    ENSRNOP00000106262.1, ENSRNOT00000141058.1
    Conserved Domains (1) summary
    cl02495
    Location:147 → 247
    RabGAP-TBC; Rab-GTPase-TBC domain

  10. XM_063276570.1 → XP_063132640.1  TBC1 domain family member 7 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZX17

  11. XM_063276571.1 → XP_063132641.1  TBC1 domain family member 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZX17
Nucleotide Protein Strain
Heading Accession and Version

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