U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clint1 clathrin interactor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360515, updated on 2-May-2024

Summary

Go to the top of the page Help
Official Symbol
Clint1provided by RGD
Official Full Name
clathrin interactor 1provided by RGD
Primary source
RGD:1303328
See related
Ensembl:ENSRNOG00000005406 AllianceGenome:RGD:1303328
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Enth; Epn4; Clint
Summary
Enables clathrin binding activity. Involved in clathrin coat assembly. Located in clathrin-coated vesicle. Orthologous to human CLINT1 (clathrin interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 199.1), Adrenal (RPKM 129.9) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q21
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (30799936..30854513)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (30298618..30353185)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (30833914..31007813)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480682 Neighboring gene uncharacterized LOC120095082 Neighboring gene LSM11, U7 small nuclear RNA associated Neighboring gene tRNA-histidine guanylyltransferase 1-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The clathrin interacting protein Clint/epsinR in rat testicular germ cells. Redecker P. Histochem Cell Biol, 2005 Jun. PMID 15875209
  2. Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics. Wasiak S, et al. J Cell Biol, 2002 Sep 2. PMID 12213833, Free PMC Article
  3. Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. Kalthoff C, et al. Mol Biol Cell, 2002 Nov. PMID 12429846, Free PMC Article
  4. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
  5. D-amino acid oxidase activity is inhibited by an interaction with bassoon protein at the presynaptic active zone. Popiolek M, et al. J Biol Chem, 2011 Aug 19. PMID 21700703, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clint/epsinR/enthoprotin has been identified in the Golgi region of spermatocytes.
    Title: The clathrin interacting protein Clint/epsinR in rat testicular germ cells.
  2. a novel clathrin-associated protein - enthoprotin ((Enth) identified through subcellular proteomics; data suggest a role in clathrin-mediated budding on internal membranes.
    Title: Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables clathrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in clathrin coat assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
clathrin interactor 1
Names
enthoprotin
epsin 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415157.1 → NP_001402086.1  clathrin interactor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    30799936..30854513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767689.3 → XP_008765911.2  clathrin interactor 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JW94, A0A8I5Y9G0
    Related
    ENSRNOP00000069793.2
    Conserved Domains (2) summary
    pfam09606
    Location:507 → 634
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cd16989
    Location:24 → 149
    ENTH_EpsinR; Epsin N-Terminal Homology (ENTH) domain of Epsin-related protein
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous