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ced-6 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35971, updated on 10-May-2024

Summary

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Official Symbol
ced-6provided by FlyBase
Primary source
FLYBASE:FBgn0029092
Locus tag
Dmel_CG11804
See related
AllianceGenome:FB:FBgn0029092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Ced-6; CED-6; ced6; CG11804; dced-6; dCed-6; dCED-6; dced6; Dmel\CG11804; drced-6; drCed-6; drCed6
Summary
Involved in apoptotic cell clearance; mushroom body development; and neuron remodeling. Is expressed in several structures, including adult head; brain; embryonic/larval garland cell; and neuropil. Orthologous to human GULP1 (GULP PTB domain containing engulfment adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See ced-6 in Genome Data Viewer
Location:
45D7-45D8; 2-60 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9434669..9444937, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5322174..5332442, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene preli-like Neighboring gene Pyruvate dehydrogenase kinase Neighboring gene long non-coding RNA:CR45321 Neighboring gene Calmodulin-binding transcription activator Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. TU-tagging: cell type-specific RNA isolation from intact complex tissues. Miller MR, et al. Nat Methods, 2009 Jun. PMID 19430475, Free PMC Article
  2. Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. Ziegenfuss JS, et al. Nat Neurosci, 2012 Jun 17. PMID 22706267, Free PMC Article
  3. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Logan MA, et al. Nat Neurosci, 2012 Mar 18. PMID 22426252, Free PMC Article
  4. Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris. Fuentes-Medel Y, et al. PLoS Biol, 2009 Aug. PMID 19707574, Free PMC Article
  5. Ensheathing glia function as phagocytes in the adult Drosophila brain. Doherty J, et al. J Neurosci, 2009 Apr 15. PMID 19369546, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ced-6 is essential for axon pruning and the removal of living neurons during development.
    Title: Essential role of the apoptotic cell engulfment genes draper and ced-6 in programmed axon pruning during Drosophila metamorphosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
ced-6
Names
CG11804-PA
CG11804-PB
CG11804-PC
CG11804-PD
CG11804-PF
ced-6-PA
ced-6-PB
ced-6-PC
ced-6-PD
ced-6-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9434669..9444937 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259296.2 → NP_001246225.1  ced-6, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246225.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E0R983
    Conserved Domains (2) summary
    cd01273
    Location:92 → 261
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl01891
    Location:233 → 304
    AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)

  2. NM_136644.3 → NP_610488.1  ced-6, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610488.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUY7
    UniProtKB/TrEMBL
    E2QC90
    Related
    FBpp0087632
    Conserved Domains (2) summary
    cd01273
    Location:76 → 245
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl01891
    Location:217 → 288
    AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)

  3. NM_001259297.2 → NP_001246226.2  ced-6, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246226.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K730
    Conserved Domains (2) summary
    cd01273
    Location:76 → 245
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl01891
    Location:217 → 288
    AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)

  4. NM_165676.2 → NP_724790.1  ced-6, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724790.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUY7
    UniProtKB/TrEMBL
    E2QC90
    Related
    FBpp0087631
    Conserved Domains (2) summary
    cd01273
    Location:76 → 245
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl01891
    Location:217 → 288
    AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)

  5. NM_165675.3 → NP_724789.1  ced-6, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724789.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JUY7
    UniProtKB/TrEMBL
    E2QC90
    Related
    FBpp0087633
    Conserved Domains (2) summary
    cd01273
    Location:76 → 245
    PTB_CED-6; Cell death protein 6 homolog (CED-6/GULP1) Phosphotyrosine-binding (PTB) domain
    cl01891
    Location:217 → 288
    AceK; Isocitrate dehydrogenase kinase/phosphatase (AceK)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K730 A0A0B4K730
E0R983 E0R983
E2QC90 E2QC90
Q7JUY7.1 Q7JUY7

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