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CG8738 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35855, updated on 18-Sep-2024

Summary

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Official Symbol
CG8738provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0033321
Locus tag
Dmel_CG8738
See related
AllianceGenome:FB:FBgn0033321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c-SPH121; cSPH121; Dmel\CG8738; SPH121
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in embryonic/larval fat body. Orthologous to human TPSAB1 (tryptase alpha/beta 1) and TPSD1 (tryptase delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
44E2-44E2; 2-59 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8696428..8698583)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4583933..4586088)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Leucine-CAG 1-1 Neighboring gene Jonah 44E Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster clip-domain serine proteases: Structure, function and regulation. Veillard F, et al. Biochimie, 2016 Mar. PMID 26453810
  2. Transcriptome Analysis of Drosophila melanogaster Third Instar Larval Ring Glands Points to Novel Functions and Uncovers a Cytochrome p450 Required for Development. Christesen D, et al. G3 (Bethesda), 2017 Feb 9. PMID 27974438, Free PMC Article
  3. Evolutionary dynamics of immune-related genes and pathways in disease-vector mosquitoes. Waterhouse RM, et al. Science, 2007 Jun 22. PMID 17588928, Free PMC Article
  4. Immunity-related genes and gene families in Anopheles gambiae. Christophides GK, et al. Science, 2002 Oct 4. PMID 12364793
  5. Enhanced function annotations for Drosophila serine proteases: a case study for systematic annotation of multi-member gene families. Shah PK, et al. Gene, 2008 Jan 15. PMID 17996400

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables serine-type endopeptidase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8738-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8696428..8698583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136559.3 → NP_610403.1  uncharacterized protein Dmel_CG8738 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610403.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7H8, Q8MQM9
    Related
    FBpp0087784
    Conserved Domains (2) summary
    smart00020
    Location:207 → 444
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:207 → 447
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1Z7H8 A1Z7H8
Q8MQM9 Q8MQM9

Gene LinkOut

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