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CG8708 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35792, updated on 10-May-2024

Summary

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Official Symbol
CG8708provided by FlyBase
Primary source
FLYBASE:FBgn0033271
Locus tag
Dmel_CG8708
See related
AllianceGenome:FB:FBgn0033271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.114; anon-WO0144478.10; dC1GalT2; Dmel\CG8708
Summary
Enables beta-1,3-galactosyltransferase activity. Involved in protein glycosylation. Located in Golgi medial cisterna. Is expressed in adult head; gland; male reproductive system; and salivary gland body primordium. Orthologous to human C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See CG8708 in Genome Data Viewer
Location:
44B5-44B7; 2-58 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8159406..8161565, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4046911..4049070, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44068 Neighboring gene transfer RNA:Isoleucine-AAT 1-2 Neighboring gene pseudo Neighboring gene Ras-related GTP binding C/D Neighboring gene uncharacterized protein Neighboring gene Rs1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of the Drosophila core 1 beta1,3-galactosyltransferase gene that synthesizes T antigen in the embryonic central nervous system and hemocytes. Yoshida H, et al. Glycobiology, 2008 Dec. PMID 18824562
  2. Cloning and expression of human core 1 beta1,3-galactosyltransferase. Ju T, et al. J Biol Chem, 2002 Jan 4. PMID 11677243
  3. Characterization of mucin-type core-1 beta1-3 galactosyltransferase homologous enzymes in Drosophila melanogaster. Müller R, et al. FEBS J, 2005 Sep. PMID 16128800
  4. Cisterna-specific localization of glycosylation-related proteins to the Golgi apparatus. Yamamoto-Hino M, et al. Cell Struct Funct, 2012. PMID 22251795
  5. Requirement for a core 1 galactosyltransferase in the Drosophila nervous system. Lin YR, et al. Dev Dyn, 2008 Dec. PMID 18985719, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables beta-1,3-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in O-glycan processing, core 1 IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi medial cisterna IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8708-PB
CG8708-PC
CG8708-PD
NP_001246201.1
NP_610360.2
NP_724653.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8159406..8161565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259272.2 → NP_001246201.1  uncharacterized protein Dmel_CG8708, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246201.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K711, H1UUF8
    Conserved Domains (1) summary
    pfam10243
    Location:379 → 443
    MIP-T3; Microtubule-binding protein MIP-T3

  2. NM_136516.4 → NP_610360.2  uncharacterized protein Dmel_CG8708, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610360.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UUF8, Q7JRF9
    Conserved Domains (1) summary
    pfam10243
    Location:385 → 449
    MIP-T3; Microtubule-binding protein MIP-T3

  3. NM_165594.3 → NP_724653.1  uncharacterized protein Dmel_CG8708, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H1UUF8, Q7JRF9
    Related
    FBpp0087885
    Conserved Domains (1) summary
    pfam10243
    Location:385 → 449
    MIP-T3; Microtubule-binding protein MIP-T3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K711 A0A0B4K711
Q7JRF9 Q7JRF9
Q7K509 Q7K509

Gene LinkOut

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