Hr38 Hormone receptor-like in 38 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hr38provided by FlyBase
Official Full Name: Hormone receptor-like in 38provided by FlyBase
Primary source: FLYBASE:FBgn0014859
Locus tag: Dmel_CG1864
See related: AllianceGenome:FB:FBgn0014859
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 38E.3; 38E.7; CG1864; dhr38; dHR38; Dhr38; DHR38; Dmel\CG1864; hr38; HR38; l(2)02306; NR4A4
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cuticle development and regulation of adult chitin-containing cuticle pigmentation. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including embryonic/larval brain; embryonic/larval gut; embryonic/larval somatic muscle cell; integumentary system; and presumptive embryonic/larval peripheral nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease and extraskeletal myxoid chondrosarcoma. Orthologous to several human genes including NR4A2 (nuclear receptor subfamily 4 group A member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 38D5-38E3; 2-54 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (20683462..20714588, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (20683462..20714588, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Hr38 decreases ethanol tolerance and causes ethanol preference. Hr38 functions as an immediate early transcription factor that promotes ethanol behavioral plasticity.
Title: Mef2 induction of the immediate early gene Hr38/Nr4a is terminated by Sirt1 to promote ethanol tolerance.
Hr38 was identified as a novel immediate early gene that is transiently expressed in the male silkmoth Bombyx mori by female odor stimulation. Hr38 was also used as a neural activity marker in the fly Drosophila melanogaster.
Title: Visualization of neural activity in insect brains using a conserved immediate early gene, Hr38.
DHR38 might modulate the activity of the Usp-EcR heterodimer by forming complexes with both of its components
Title: The composite nature of the interaction between nuclear receptors EcR and DHR38.
dHR38-N-Terminal domain exhibits a characteristic reminiscent of pre-molten globule-like intrinsically disordered proteins
Title: Intrinsic disorder of Drosophila melanogaster hormone receptor 38 N-terminal domain.
Nutritional regulation of DHR38 expression maintains the proper uptake and storage of glycogen during the growing larval stage of development.
Title: The Drosophila NR4A nuclear receptor DHR38 regulates carbohydrate metabolism and glycogen storage.
DHR38(Y214) mutants display minor effects on ecdysone-regulated transcription at the onset of metamorphosis
Title: Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion.
DHR38 may act as a positive regulator of neural Ddc expression
Title: The orphan nuclear receptor DHR38 influences transcription of the DOPA decarboxylase gene in epidermal and neural tissues of Drosophila melanogaster.
Gain and loss of function studies also implicate DHR38, the Drosophila homolog of vertebrate NGFI-B-type nuclear receptors, as an important activator of the ACP65A gene.
Title: The Drosophila ACP65A cuticle gene: deletion scanning analysis of cis-regulatory sequences and regulation by DHR38.
A second ecdysteroid signaling pathway is mediated by DHR38. DHR38 also heterodimerizes with Ultraspiralcle, and this complex responds to a distinct class of ecdysteroids in a manner that is independent of the ecdysteroid receptor.
Title: The Drosophila orphan nuclear receptor DHR38 mediates an atypical ecdysteroid signaling pathway.
Hr38 is a nuclear receptor which can assume an active conformation in the absence of a ligand agonist.
Title: Activation incarnate.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0299 (e-PCR)
- UniSTS:13568

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables core promoter sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclear glucocorticoid receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to corticotropin-releasing hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of adult chitin-containing cuticle pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: hormone receptor-like in 38

Names: CG1864-PB; CG1864-PD; Hr38-PB; Hr38-PD; hormone receptor 38; hormone receptor-like 38

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

20683462..20714588 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169553.2 → NP_001163024.1 hormone receptor-like in 38, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163024.1

Status: REVIEWED

UniProtKB/TrEMBL

E1JHM7

Conserved Domains (2) summary

cd07072
Location:607 → 836

NR_LBD_DHR38_like; Ligand binding domain of DHR38_like proteins, members of the nuclear receptor superfamily

cd06969
Location:505 → 579

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B
NM_057771.4 → NP_477119.1 hormone receptor-like in 38, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477119.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O18383, P49869, Q9VIK4

Related

FBpp0080927

Conserved Domains (2) summary

cd07072
Location:849 → 1078

NR_LBD_DHR38_like; Ligand binding domain of DHR38_like proteins, members of the nuclear receptor superfamily

cd06969
Location:747 → 821

NR_DBD_NGFI-B; DNA-binding domain of the orphan nuclear receptor, nerve growth factor-induced-B