CycE Cyclin E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CycEprovided by FlyBase
Official Full Name: Cyclin Eprovided by FlyBase
Primary source: FLYBASE:FBgn0010382
Locus tag: Dmel_CG3938
See related: AllianceGenome:FB:FBgn0010382
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3938; BG:DS07108.3; br37; cdi7; Cdi7; CDI7; CG3938; Cyc; Cyc E; Cyc-E; cycE; CYCE; CycEI; CyclE; cyclin E; cyclin-E; cycline; cyclinE; CyE-1; CyeE; D-CycE; dCycE; dm-cycE; DmcycE; DmCycE; DmcyclinE; Dmel\CG3938; fond; l(2)05206; l(2)35Dd; l(2)br37; l(2)k02514; l(2)k02602; l(2)k05007; l35Dd
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including gamete generation; nervous system development; and regulation of mitotic cell cycle phase transition. Located in nucleus. Is expressed in several structures, including central nervous system; extended germ band embryo; germ layer; ovariole; and stage 5 embryo. Human ortholog(s) of this gene implicated in breast adenocarcinoma and castration-resistant prostate carcinoma. Orthologous to human CCNE1 (cyclin E1) and CCNE2 (cyclin E2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 35D4-35D4; 2-51 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (15727581..15748150, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (15727581..15748150, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin E and Cdk1 regulate the termination of germline transit-amplification process in Drosophila testis.
Title: Cyclin E and Cdk1 regulate the termination of germline transit-amplification process in Drosophila testis.
Apt-mediated expression of Hh and cyclin E can direct proliferation of Hh-expressing cells and simultaneous growth, patterning and differentiation of Hh-recipient cells.
Title: Apontic directly activates hedgehog and cyclin E for proper organ growth and patterning.
These findings reveal a Gcm-Apt-CycE axis that regulates neuroblast and glia cell differentiation.
Title: The transcriptional factor Apt regulates neuroblast differentiation through activating CycE expression.
These findings suggest that spatiotemporal expression of transcription factor Sd induces differential growth regulation by Yki during wing disc development, highlighting coordination between Yki and CycE to control growth and maintain homeostasis.
Title: Differential Regulation of Cyclin E by Yorkie-Scalloped Signaling in Organ Development.
we show that Ewg repression of Cyclin E expression is required for the arrest of myoblast proliferation and initiate myoblast fusion and terminal differentiation
Title: Spatio-temporal coordination of cell cycle exit, fusion and differentiation of adult muscle precursors by Drosophila Erect wing (Ewg).
we provide genetic evidences, that the Ama-Nrt-Abl-pathway regulates CycE expression by altering the function of the Hippo effector Yorkie in embryonic NBs
Title: Cell-Autonomous and Non-cell-autonomous Function of Hox Genes Specify Segmental Neuroblast Identity in the Gnathal Region of the Embryonic CNS in Drosophila.
We further detected that reduced level of GRK2 induced a small cell cycle arrest at G2/M phase by enhancing the expression of cyclin A, B1, and E
Title: GRK2 negatively regulates IGF-1R signaling pathway and cyclins' expression in HepG2 cells.
CycE and Cdk2 are required for germline stem cell proliferation.
Title: Cyclin E controls Drosophila female germline stem cell maintenance independently of its role in proliferation by modulating responsiveness to niche signals.
p53-mediated regulation of ectopic neural stem cells (NSC) self-renewal through the Ago/Cyc E axis becomes particularly important when NSC homeostasis is perturbed.
Title: dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E.
analysis of Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system
Title: Abdominal-A mediated repression of Cyclin E expression during cell-fate specification in the Drosophila central nervous system.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0007 (e-PCR)
- UniSTS:1165

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell proliferation involved in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eggshell chorion gene amplification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron fate specification	IDA Inferred from Direct Assay more info	PubMed
involved_in peripheral nervous system development	IEP Inferred from Expression Pattern more info	PubMed
involved_in pole cell development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment of blood-brain barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of exit from mitosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory organ precursor cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somatic stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
involved_in ventral cord development	HMP more info	PubMed
involved_in wing disc development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin E1-CDK2 complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin E

Names: CG3938-PA; CG3938-PB; CG3938-PC; CG3938-PD; CG3938-PE; CG3938-PF; CycE-PA; CycE-PB; CycE-PC; CycE-PD; CycE-PE; CycE-PF; Cyclin-dependent kinase interactor 7; cyclin; cyclin-E; cyclinE; cycline E; dCyclinE; fondue

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

15727581..15748150 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165125.3 → NP_723926.1 cyclin E, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723926.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54733, Q24479, Q95RP5, Q9V3B3, Q9V456

UniProtKB/TrEMBL

A4V0R4

Related

FBpp0080331

Conserved Domains (2) summary

pfam00134
Location:330 → 459

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:514 → 568

Cyclin_C; Cyclin, C-terminal domain
NM_165124.3 → NP_723925.1 cyclin E, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723925.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54733, Q24479, Q95RP5, Q9V3B3, Q9V456

UniProtKB/TrEMBL

A4V0R4

Related

FBpp0080334

Conserved Domains (2) summary

pfam00134
Location:330 → 459

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:514 → 568

Cyclin_C; Cyclin, C-terminal domain
NM_057612.5 → NP_476960.1 cyclin E, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476960.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54733

Related

FBpp0080335

Conserved Domains (2) summary

pfam00134
Location:223 → 352

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:407 → 461

Cyclin_C; Cyclin, C-terminal domain
NM_057611.5 → NP_476959.1 cyclin E, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476959.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54733, Q24479, Q95RP5, Q9V3B3, Q9V456

UniProtKB/TrEMBL

A4V0R4

Related

FBpp0080332

Conserved Domains (2) summary

pfam00134
Location:330 → 459

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:514 → 568

Cyclin_C; Cyclin, C-terminal domain
NM_001259108.2 → NP_001246037.1 cyclin E, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001246037.1

Status: REVIEWED

UniProtKB/TrEMBL

M9NDQ2

Conserved Domains (2) summary

pfam00134
Location:333 → 462

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:517 → 571

Cyclin_C; Cyclin, C-terminal domain
NM_165123.3 → NP_723924.1 cyclin E, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723924.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54733, Q24479, Q95RP5, Q9V3B3, Q9V456

UniProtKB/TrEMBL

A4V0R4

Related

FBpp0080333

Conserved Domains (2) summary

pfam00134
Location:330 → 459

Cyclin_N; Cyclin, N-terminal domain

pfam02984
Location:514 → 568

Cyclin_C; Cyclin, C-terminal domain