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Hsp60D Heat shock protein 60D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34763, updated on 10-May-2024

Summary

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Official Symbol
Hsp60Dprovided by FlyBase
Official Full Name
Heat shock protein 60Dprovided by FlyBase
Primary source
FLYBASE:FBgn0032525
Locus tag
Dmel_CG16954
See related
AllianceGenome:FB:FBgn0032525
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16954; Dmel\CG16954; HSP60D
Summary
Predicted to enable ATP hydrolysis activity and chaperone binding activity. Involved in apoptotic process. Predicted to be active in mitochondrial inner membrane and mitochondrial matrix. Human ortholog(s) of this gene implicated in artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See Hsp60D in Genome Data Viewer
Location:
34C1-34C1; 2-48 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13447538..13449497, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13447538..13449497, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45683 Neighboring gene tehao Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene long non-coding RNA:CR45684 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Delayed discovery of Hsp60 and subsequent characterization of moonlighting functions of multiple Hsp60 genes in Drosophila: a personal historical perspective. Lakhotia SC. J Genet, 2022. PMID 36330787
  2. Heat shock genes - integrating cell survival and death. Arya R, et al. J Biosci, 2007 Apr. PMID 17536179
  3. Drosophila melanogaster mitochondrial Hsp22: a role in resistance to oxidative stress, aging and the mitochondrial unfolding protein response. Morrow G, et al. Biogerontology, 2016 Feb. PMID 26155908
  4. The Hsp60C gene in the 25F cytogenetic region in Drosophila melanogaster is essential for tracheal development and fertility. Sarkar S, et al. J Genet, 2005 Dec. PMID 16385159
  5. Elevation of major constitutive heat shock proteins is heat shock factor independent and essential for establishment and growth of Lgl loss and Yorkie gain-mediated tumors in Drosophila. Singh G, et al. Cell Stress Chaperones, 2022 Jul. PMID 35704239, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The downregulation of Hsp60D protein blocks caspase-dependent induced apoptosis.
    Title: Hsp60D is essential for caspase-mediated induced apoptosis in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic mitochondrial changes IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heat shock protein 60D
Names
CG16954-PA
CG16954-PB
Hsp60D-PA
Hsp60D-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    13447538..13449497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135812.2 → NP_609656.1  heat shock protein 60D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609656.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJX7
    Related
    FBpp0080095, FBtr0080517
    Conserved Domains (2) summary
    PTZ00114
    Location:13 → 546
    PTZ00114; Heat shock protein 60; Provisional
    cd03344
    Location:18 → 536
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...

  2. NM_165043.2 → NP_723818.1  heat shock protein 60D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723818.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJX7
    Related
    FBpp0080096
    Conserved Domains (2) summary
    PTZ00114
    Location:13 → 546
    PTZ00114; Heat shock protein 60; Provisional
    cd03344
    Location:18 → 536
    GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJX7 Q9VJX7

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