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CG6180 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34683, updated on 18-Sep-2024

Summary

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Official Symbol
CG6180provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0032453
Locus tag
Dmel_CG6180
See related
AllianceGenome:FB:FBgn0032453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG6180
Summary
Predicted to be involved in negative regulation of ERK1 and ERK2 cascade. Predicted to be located in cytosol. Is expressed in several structures, including adult heart; embryonic/larval midgut; embryonic/larval midgut primordium; posterior endoderm; and spermatozoon. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
33F3-33F3; 2-47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12707661..12708680)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12707661..12708680)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene spichthyin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PIH1 domain containing 1 Neighboring gene Multidrug-Resistance like Protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and characterization of the PEBP homolog genes from Drosophila. Rautureau G, et al. Arch Insect Biochem Physiol, 2009 Jun. PMID 19309003
  2. Juvenile hormone counteracts the bHLH-PAS transcription factors MET and GCE to prevent caspase-dependent programmed cell death in Drosophila. Liu Y, et al. Development, 2009 Jun. PMID 19465595
  3. Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells. Siddiqui NU, et al. Genome Biol, 2012 Feb 20. PMID 22348290, Free PMC Article
  4. The hemolymph proteome of fed and starved Drosophila larvae. Handke B, et al. PLoS One, 2013. PMID 23840627, Free PMC Article
  5. Leishmania amazonensis sabotages host cell SUMOylation for intracellular survival. Okuda K, et al. iScience, 2022 Sep 16. PMID 36060064, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
uncharacterized protein
Names
CG6180-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    12707661..12708680
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135744.2 → NP_609588.1  uncharacterized protein Dmel_CG6180 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609588.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0L1, Q9VK60
    Related
    FBpp0079979
    Conserved Domains (1) summary
    cd00866
    Location:100 → 242
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VK60 Q9VK60

Gene LinkOut

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