bun bunched [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: bunprovided by FlyBase
Official Full Name: bunchedprovided by FlyBase
Primary source: FLYBASE:FBgn0259176
Locus tag: Dmel_CG42281
See related: AllianceGenome:FB:FBgn0259176
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1550; bnc; Bun; BunA; CG31857; CG42281; CG5461; Dmel\CG42281; Dm_2L:60722; EP(2)0488; l(2)00255; l(2)02687; l(2)05479; l(2)06475; l(2)k02903; l(2)rI043; shs; TSC-22; Tsc22
Old locus tag: Dmel_CG31857; Dmel_CG5461
Summary: Predicted to enable protein homodimerization activity. Involved in several processes, including intestinal stem cell homeostasis; nervous system development; and ovarian follicle cell development. Located in cytosol. Is expressed in several structures, including blastoderm embryo; central nervous system; ectoderm anlage; germ layer; and gut section. Orthologous to several human genes including TSC22D1 (TSC22 domain family member 1) and TSC22D2 (TSC22 domain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 33E5-33E9; 2-46 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12455540..12546611, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12455540..12546611, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The data suggest the model that Bunched and Madm functionally interact with the TOR pathway in the cytoplasm to regulate the growth and subsequent division of intestinal stem cells.
Title: Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila.
Bunched, a negative regulator of Notch, is involved in sleep homeostasis through a neuron-glia signal pathway.
Title: Notch signaling modulates sleep homeostasis and learning after sleep deprivation in Drosophila.
bun acts as a specific factor in regulating neuroblast mitotic activity during the development of alpha/beta neurons.
Title: Bunched specifically regulates alpha/beta mushroom body neuronal cell proliferation during metamorphosis.
Drosophila TSC-22/DIP/Bun proteins are necessary for cellular growth, proliferation, and survival both in culture and in an epithelial context.
Title: The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival.
we hypothesize that the long TSC-22 protein is a functional homolog of BunA in growth regulation, and that it is antagonized by the short TSC-22 protein
Title: Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth.
BunDN has dominant negative activity useful to identify bun functions and genetic interactions that occur during tissue patterning.
Title: A dominant negative allele of the Drosophila leucine zipper protein Bunched blocks bunched function during tissue patterning.
In anterior follicle cells exposed to a Dpp morphogen gradient, high and low levels of slbo and bun, respectively, are established by modulation of Notch signaling to direct threshold cell fates.
Title: Notch signaling links interactions between the C/EBP homolog slow border cells and the GILZ homolog bunched during cell migration.
bun regulates the level of Notch stimulation to position the boundary between centripetally migrating and stationary columnar follicle cells
Title: Bunched sets a boundary for Notch signaling to pattern anterior eggshell structures during Drosophila oogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0246 (e-PCR)
- UniSTS:60004

Dm0002 (e-PCR)
- UniSTS:66408

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in chorion-containing eggshell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in follicle cell of egg chamber migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bunched

Names: CG42281-PA; CG42281-PB; CG42281-PC; CG42281-PD; CG42281-PE; CG42281-PF; CG42281-PG; CG42281-PH; CG42281-PO; CG42281-PP; bun-PA; bun-PB; bun-PC; bun-PD; bun-PE; bun-PF; bun-PG; bun-PH; bun-PO; bun-PP; short sighted; short-sighted; shortsighted