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Pde1c Phosphodiesterase 1c [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34594, updated on 10-May-2024

Summary

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Official Symbol
Pde1cprovided by FlyBase
Official Full Name
Phosphodiesterase 1cprovided by FlyBase
Primary source
FLYBASE:FBgn0264815
Locus tag
Dmel_CG44007
See related
AllianceGenome:FB:FBgn0264815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14940; CG14942; CG14943; CG14944; CG31757; CG31758; CG42325; CG44007; Dmel\CG44007; FBgn0264815; mdcds_1440; PDE1; PDE1c; PDE1C
Old locus tag
Dmel_CG14940; Dmel_CG14943; Dmel_CG14944; Dmel_CG31757; Dmel_CG31758; Dmel_CG42325
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity and calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity. Involved in cAMP metabolic process; cGMP metabolic process; and male mating behavior. Located in extracellular space. Is expressed in adult head; embryonic/larval circulatory system; larval midline neurons; procrystal cell; and ventral midline of embryo. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to several human genes including PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pde1c in Genome Data Viewer
Location:
33A2-33B1; 2-45 cM
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11814156..11928572, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11814156..11928572, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene crooked legs Neighboring gene Cyclin Y Neighboring gene long non-coding RNA:CR45013 Neighboring gene long non-coding RNA:CR45014 Neighboring gene long non-coding RNA:CR43937 Neighboring gene antisense RNA:CR43936 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene extra sexcombs Neighboring gene Seminal fluid protein 33A4 Neighboring gene Seminal fluid protein 33A2 Neighboring gene Seminal fluid protein 33A3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Maltase B1 Neighboring gene Maltase B2 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 33a Neighboring gene Odorant receptor 33b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MicroRNA-133 Targets Phosphodiesterase 1C in Drosophila and Human Oral Cancer Cells to Regulate Epithelial-Mesenchymal Transition. Jung JE, et al. J Cancer, 2021. PMID 34335946, Free PMC Article
  2. Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster. Morton DB, et al. Genetics, 2010 Sep. PMID 20551439, Free PMC Article
  3. Knockdown of a Cyclic Nucleotide-Gated Ion Channel Impairs Locomotor Activity and Recovery From Hypoxia in Adult Drosophila melanogaster. Qiu S, et al. Front Physiol, 2022. PMID 35530504, Free PMC Article
  4. NMDA Receptor-mediated Ca2+ Influx in the Absence of Mg2+ Block Disrupts Rest: Activity Rhythms in Drosophila. Song Q, et al. Sleep, 2017 Dec 1. PMID 29029290
  5. Antagonistic pleiotropy and mutation accumulation contribute to age-related decline in stress response. Everman ER, et al. Evolution, 2018 Feb. PMID 29214647

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. physiological function of Pde1c in Drosophila melanogaster
    Title: Infertility and male mating behavior deficits associated with Pde1c in Drosophila melanogaster.
  2. The Drosophila genome encodes five novel PDE genes in addition to dunce. Predicted PDE sequences of Drosophila show highly conserved critical domains when compared with human PDEs.
    Title: Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cGMP metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in male mating behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sexual reproduction HEP PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 

General protein information

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Preferred Names
phosphodiesterase 1c
Names
CG44007-PB
CG44007-PC
CG44007-PD
CG44007-PE
CG44007-PG
CG44007-PH
CG44007-PJ
CG44007-PK
CG44007-PL
Pde1c-PB
Pde1c-PC
Pde1c-PD
Pde1c-PE
Pde1c-PG
Pde1c-PH
Pde1c-PJ
Pde1c-PK
Pde1c-PL
NP_001137816.1
NP_001137817.1
NP_001137818.1
NP_001137819.2
NP_001137820.1
NP_001245994.1
NP_001245995.2
NP_001260395.1
NP_609520.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11814156..11928572 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144348.4 → NP_001137820.1  phosphodiesterase 1c, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137820.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZV4, Q9VKE9
    UniProtKB/TrEMBL
    Q8SXR0
    Conserved Domains (2) summary
    pfam00233
    Location:468 → 687
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:327 → 383
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  2. NM_135676.6 → NP_609520.1  phosphodiesterase 1c, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609520.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZV4
    Related
    FBpp0306254
    Conserved Domains (2) summary
    pfam00233
    Location:239 → 458
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:98 → 154
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  3. NM_001259065.2 → NP_001245994.1  phosphodiesterase 1c, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245994.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF02
    Conserved Domains (2) summary
    pfam00233
    Location:586 → 805
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:445 → 501
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  4. NM_001273466.1 → NP_001260395.1  phosphodiesterase 1c, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDA0
    Conserved Domains (2) summary
    pfam00233
    Location:792 → 1011
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:651 → 707
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  5. NM_001259066.2 → NP_001245995.2  phosphodiesterase 1c, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245995.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXR0, X2BZJ7
    Conserved Domains (2) summary
    pfam00233
    Location:489 → 708
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:348 → 404
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  6. NM_001144345.3 → NP_001137817.1  phosphodiesterase 1c, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137817.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZV2
    Conserved Domains (2) summary
    pfam00233
    Location:807 → 1026
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:666 → 722
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  7. NM_001144347.3 → NP_001137819.2  phosphodiesterase 1c, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137819.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZV3
    Conserved Domains (2) summary
    pfam00233
    Location:643 → 862
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:502 → 558
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  8. NM_001144344.2 → NP_001137816.1  phosphodiesterase 1c, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137816.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7YZV4, Q9VKE9
    UniProtKB/TrEMBL
    Q8SXR0
    Conserved Domains (2) summary
    pfam00233
    Location:468 → 687
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:327 → 383
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  9. NM_001144346.3 → NP_001137818.1  phosphodiesterase 1c, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137818.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7YZV1
    Conserved Domains (2) summary
    pfam00233
    Location:771 → 990
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:630 → 686
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7YZV1 B7YZV1
B7YZV2 B7YZV2
B7YZV3 B7YZV3
B7YZV4.1 B7YZV4
M9NF02 M9NF02
M9PDA0 M9PDA0
Q8SXR0 Q8SXR0
X2BZJ7 X2BZJ7

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