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baf barrier to autointegration factor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34095, updated on 10-May-2024

Summary

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Official Symbol
bafprovided by FlyBase
Official Full Name
barrier to autointegration factorprovided by FlyBase
Primary source
FLYBASE:FBgn0031977
Locus tag
Dmel_CG7380
See related
AllianceGenome:FB:FBgn0031977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0172774.178; BAF; CG7380; dBAF; Dmel\CG7380
Summary
Predicted to enable DNA binding activity. Involved in chromosome condensation and oocyte karyosome formation. Located in cytoplasm; nuclear envelope; and nucleoplasm. Is expressed in adult heart. Human ortholog(s) of this gene implicated in progeria. Orthologous to several human genes including BANF1 (BAF nuclear assembly factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See baf in Genome Data Viewer
Location:
28D3-28D3; 2-29 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8029462..8030565)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8029462..8030565)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Glycine N-acyltransferase Neighboring gene Transglutaminase Neighboring gene uncharacterized protein Neighboring gene Connector of kinase to AP-1 Neighboring gene Coiled-coil domain containing 53 Neighboring gene Ribosomal protein L36A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila. Furukawa K, et al. J Struct Biol, 2007 Nov. PMID 17904382
  2. Analysis of a rare progeria variant of Barrier-to-autointegration factor in Drosophila connects centromere function to tissue homeostasis. Duan T, et al. Cell Mol Life Sci, 2023 Feb 26. PMID 36842139, Free PMC Article
  3. NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus. Lancaster OM, et al. J Cell Biol, 2007 Dec 3. PMID 18039935, Free PMC Article
  4. Two novel LEM-domain proteins are splice products of the annotated Drosophila melanogaster gene CG9424 (Bocksbeutel). Wagner N, et al. Eur J Cell Biol, 2004 Jan. PMID 15035436
  5. Checkpoint activation drives global gene expression changes in Drosophila nuclear lamina mutants. Kitzman SC, et al. G3 (Bethesda), 2022 Feb 4. PMID 34893833, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages.
    Title: Baf-mediated transcriptional regulation of teashirt is essential for the development of neural progenitor cell lineages.
  2. Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
    Title: Recruitment of BAF to the nuclear envelope couples the LINC complex to endoreplication.
  3. BAF phosphorylation by NHK-1 disrupts anchorage of chromosomes to the nuclear envelope, allowing karyosome formation in oocytes.
    Title: NHK-1 phosphorylates BAF to allow karyosome formation in the Drosophila oocyte nucleus.
  4. BAF disappears at an early stage due to caspase activity when apoptosis is induced by hid, and its depletion in mutants is sufficient in itself to induce cell death, suggesting it is an apoptotic mediator
    Title: BAF as a caspase-dependent mediator of nuclear apoptosis in Drosophila.
  5. BAF plays essential roles in nuclear organization and that these BAF functions are required in both M phase and interphase of the cell cycle
    Title: Barrier-to-autointegration factor plays crucial roles in cell cycle progression and nuclear organization in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome condensation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oocyte karyosome formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in condensed chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
barrier to autointegration factor
Names
Barrier-to-Autointegration factor
CG7380-PA
CG7380-PB
baf-PA
baf-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8029462..8030565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273291.1 → NP_001260220.1  barrier to autointegration factor, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260220.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XE9, Q9VLU0
    UniProtKB/TrEMBL
    M9PCH8
    Conserved Domains (1) summary
    pfam02961
    Location:2 → 87
    BAF; Barrier to autointegration factor

  2. NM_135332.4 → NP_609176.1  barrier to autointegration factor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609176.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q53XE9, Q9VLU0
    UniProtKB/TrEMBL
    M9PCH8
    Related
    FBpp0079157
    Conserved Domains (1) summary
    pfam02961
    Location:2 → 87
    BAF; Barrier to autointegration factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCH8 M9PCH8
Q9VLU0.1 Q9VLU0

Gene LinkOut

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