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Pfas Phosphoribosylformylglycinamidine synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33847, updated on 10-May-2024

Summary

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Official Symbol
Pfasprovided by FlyBase
Official Full Name
Phosphoribosylformylglycinamidine synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0000052
Locus tag
Dmel_CG9127
See related
AllianceGenome:FB:FBgn0000052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
153122_at; ade2; Ade2; CG9127; Dmel\CG9127; Paics; pfas; pym
Summary
Enables phosphoribosylformylglycinamidine synthase activity. Involved in purine nucleobase biosynthetic process. Predicted to be located in cytoplasm. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval lymph gland; extended germ band embryo; gut section; and yolk nucleus. Orthologous to human PFAS (phosphoribosylformylglycinamidine synthase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Pfas in Genome Data Viewer
Location:
26B3-26B3; 2-18 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6041181..6046050, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6041181..6046050, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene myotubularin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-966 stem loop Neighboring gene uncharacterized protein Neighboring gene slowmo Neighboring gene Inositol phosphatase interacting protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ade2 Functions in the Drosophila Fat Body To Promote Sleep. Yurgel ME, et al. G3 (Bethesda), 2018 Nov 6. PMID 30249751, Free PMC Article
  2. The adenosine2 gene of Drosophila melanogaster encodes a formylglycineamide ribotide amidotransferase. Tiong SY, et al. Genome, 1993 Oct. PMID 8270203
  3. The adenosine 2 locus of Drosophila melanogaster: clarification of the map position and eye phenotype of the ade2 mutant. Keizer C, et al. Biochem Genet, 1989 Jun. PMID 2508621
  4. Two Drosophila melanogaster mutations block successive steps of de novo purine synthesis. Henikoff S, et al. Proc Natl Acad Sci U S A, 1986 Jun. PMID 3086869, Free PMC Article
  5. Nucleoside auxotrophy in Drosophila: an autosomal locus yielding mutants supplementable by purine and pyrimidine ribonucleosides. Naguib FN, et al. Mol Gen Genet, 1976 Aug 10. PMID 822279

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings suggest Ade2 functions within the fat body to promote both sleep and energy storage, providing a functional link between these processes.
    Title: Ade2 Functions in the Drosophila Fat Body To Promote Sleep.
  2. together with the fact that the EJC-disassembly activity of DmPYM is regulated, implicates PYM as an effector of EJC homeostasis in vivo.
    Title: The EJC binding and dissociating activity of PYM is regulated in Drosophila.
  3. Data show the presence of apoptosis at the cellular level in both ade2 and Prat mutants, and the upregulated gene HtrA2, which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.
    Title: A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphoribosylformylglycinamidine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylformylglycinamidine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylformylglycinamidine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phosphoribosylformylglycinamidine synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
phosphoribosylformylglycinamidine synthase
Names
CG9127-PA
CG9127-PB
CG9127-PC
Pfas-PA
Pfas-PB
Pfas-PC
adenosine 2
adenosine2
NP_477212.1
NP_723146.1
NP_723147.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6041181..6046050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164675.2 → NP_723146.1  phosphoribosylformylglycinamidine synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723146.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V099, P35421, Q6NNY9, Q9VMI7
    Related
    FBpp0078851
    Conserved Domains (4) summary
    cd02203
    Location:223 → 612
    PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
    cd02204
    Location:715 → 1004
    PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
    PLN03206
    Location:18 → 1349
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    pfam13507
    Location:1085 → 1349
    GATase_5; CobB/CobQ-like glutamine amidotransferase domain

  2. NM_057864.4 → NP_477212.1  phosphoribosylformylglycinamidine synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477212.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V099, P35421, Q6NNY9, Q9VMI7
    Related
    FBpp0078850
    Conserved Domains (4) summary
    cd02203
    Location:223 → 612
    PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
    cd02204
    Location:715 → 1004
    PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
    PLN03206
    Location:18 → 1349
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    pfam13507
    Location:1085 → 1349
    GATase_5; CobB/CobQ-like glutamine amidotransferase domain

  3. NM_164676.2 → NP_723147.1  phosphoribosylformylglycinamidine synthase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723147.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V099, P35421, Q6NNY9, Q9VMI7
    Related
    FBpp0078852
    Conserved Domains (4) summary
    cd02203
    Location:223 → 612
    PurL_repeat1; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
    cd02204
    Location:715 → 1004
    PurL_repeat2; PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, ...
    PLN03206
    Location:18 → 1349
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    pfam13507
    Location:1085 → 1349
    GATase_5; CobB/CobQ-like glutamine amidotransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35421.2 P35421

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