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FucTC alpha1,3-fucosyltransferase C [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355171, updated on 18-Sep-2024

Summary

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Official Symbol
FucTCprovided by FlyBase
Official Full Name
alpha1,3-fucosyltransferase Cprovided by FlyBase
Primary source
FLYBASE:FBgn0044872
Locus tag
Dmel_CG40305
See related
AllianceGenome:FB:FBgn0044872
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG40305; Dmel\CG40305
Summary
Predicted to enable alpha-(1->3)-fucosyltransferase activity. Predicted to be involved in fucosylation. Predicted to be located in membrane. Orthologous to several human genes including FUT3 (fucosyltransferase 3 (Lewis blood group)); FUT4 (fucosyltransferase 4); and FUT5 (fucosyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
20F3-20F3; 1-66 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (23008766..23011303, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (22410602..22413139, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene stoned A Neighboring gene stoned B Neighboring gene antisense RNA:CR45009 Neighboring gene long non-coding RNA:CR45010 Neighboring gene Rab21 Neighboring gene Cytochrome c oxidase assembly factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of core alpha 1,3-fucosylated glycans and cloning of the requisite fucosyltransferase cDNA from Drosophila melanogaster. Potential basis of the neural anti-horseadish peroxidase epitope. Fabini G, et al. J Biol Chem, 2001 Jul 27. PMID 11382750
  2. Modulation of neural carbohydrate epitope expression in Drosophila melanogaster cells. Rendic D, et al. J Biol Chem, 2006 Feb 10. PMID 16314421
  3. Neural-specific α3-fucosylation of N-linked glycans in the Drosophila embryo requires fucosyltransferase A and influences developmental signaling associated with O-glycosylation. Rendić D, et al. Glycobiology, 2010 Nov. PMID 20688784, Free PMC Article
  4. Multiple Quantitative Trait Loci Influence the Shape of a Male-Specific Genital Structure in Drosophila melanogaster. McNeil CL, et al. G3 (Bethesda), 2011 Oct. PMID 22384345, Free PMC Article
  5. Glycosylation of proteins in plants and invertebrates. Wilson IB. Curr Opin Struct Biol, 2002 Oct. PMID 12464307

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables alpha-(1->3)-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables fucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha1,3-fucosyltransferase C
Names
CG40305-PB
FucTC-PB
alpha1,3-fucosyltransferase
NP_001036320.3
  • frameshift

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    23008766..23011303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042855.4 → NP_001036320.3  alpha1,3-fucosyltransferase C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036320.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P83088, Q7PLF1
    Conserved Domains (2) summary
    pfam00852
    Location:241 → 410
    Glyco_transf_10; Glycosyltransferase family 10 (fucosyltransferase) C-term
    pfam17039
    Location:82 → 203
    Glyco_tran_10_N; Fucosyltransferase, N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P83088.4 P83088

Gene LinkOut

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Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials