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Hers Histone gene-specific Epigenetic Repressor in late S phase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33000, updated on 18-Sep-2024

Summary

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Official Symbol
Hersprovided by FlyBase
Official Full Name
Histone gene-specific Epigenetic Repressor in late S phaseprovided by FlyBase
Primary source
FLYBASE:FBgn0052529
Locus tag
Dmel_CG32529
See related
AllianceGenome:FB:FBgn0052529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11936; CG15619; CG32529; Dmel\CG32529; HERS
Summary
Enables transcription cis-regulatory region binding activity. Involved in chromatin remodeling and heterochromatin assembly. Is expressed in spermatozoon; wing hinge primordium; and wing pouch. Orthologous to human BAHD1 (bromo adjacent homology domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Hers in Genome Data Viewer
Location:
18F4-19A2; 1-64 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19866146..19908108)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19760179..19802141)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 205kD Neighboring gene THADA Neighboring gene amnesiac Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Epigenetic silencing of core histone genes by HERS in Drosophila. Ito S, et al. Mol Cell, 2012 Feb 24. PMID 22365829
  2. Drosophila FMRP controls miR-276-mediated regulation of nejire mRNA for space-filling dendrite development. Li H, et al. G3 (Bethesda), 2022 Nov 4. PMID 36102801, Free PMC Article
  3. Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. Campbell JL, et al. J Neurogenet, 2009. PMID 19863272, Free PMC Article
  4. Coordinating cell cycle-regulated histone gene expression through assembly and function of the Histone Locus Body. Duronio RJ, et al. RNA Biol, 2017 Jun 3. PMID 28059623, Free PMC Article
  5. Comparative transcriptomics between Drosophila mojavensis and D. arizonae reveals transgressive gene expression and underexpression of spermatogenesis-related genes in hybrid testes. Banho CA, et al. Sci Rep, 2021 May 10. PMID 33972659, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterochromatin formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin silencing complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
histone gene-specific epigenetic repressor in late S phase
Names
CG32529-PA
CG32529-PC
CG32529-PD
CG32529-PE
CG32529-PF
CG32529-PG
CG32529-PH
CG32529-PI
Hers-PA
Hers-PC
Hers-PD
Hers-PE
Hers-PF
Hers-PG
Hers-PH
Hers-PI

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    19866146..19908108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272807.1 → NP_001259736.1  histone gene-specific epigenetic repressor in late S phase, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259736.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NN1, Q9VWC0
    Conserved Domains (1) summary
    cd04714
    Location:2366 → 2519
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

  2. NM_134516.3 → NP_608360.2  histone gene-specific epigenetic repressor in late S phase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608360.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NN1, Q9VWC0
    Related
    FBpp0074569
    Conserved Domains (1) summary
    cd04714
    Location:2366 → 2519
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

  3. NM_001258842.1 → NP_001245771.1  histone gene-specific epigenetic repressor in late S phase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245771.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NN1, Q9VWC0
    Conserved Domains (1) summary
    cd04714
    Location:2366 → 2519
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

  4. NM_001258843.1 → NP_001245772.1  histone gene-specific epigenetic repressor in late S phase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2MGL2
    Conserved Domains (1) summary
    cd04714
    Location:1293 → 1446
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

  5. NM_001038766.3 → NP_001033855.1  histone gene-specific epigenetic repressor in late S phase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001033855.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2MGL2
    Conserved Domains (1) summary
    cd04714
    Location:1293 → 1446
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

  6. NM_001258844.1 → NP_001245773.1  histone gene-specific epigenetic repressor in late S phase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245773.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q2MGL2
    Conserved Domains (1) summary
    cd04714
    Location:1293 → 1446
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

  7. NM_167688.2 → NP_728309.1  histone gene-specific epigenetic repressor in late S phase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728309.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VWC2
    Related
    FBpp0074570
    Conserved Domains (1) summary
    cd04714
    Location:1117 → 1270
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...

  8. NM_001258845.1 → NP_001245774.1  histone gene-specific epigenetic repressor in late S phase, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245774.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NES5, Q95U13
    Conserved Domains (1) summary
    cd04714
    Location:976 → 1129
    BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NES5 M9NES5
Q2MGL2 Q2MGL2
Q5BI54 Q5BI54
Q86NN1 Q86NN1
Q95U13 Q95U13
Q9VWC0 Q9VWC0
Q9VWC2 Q9VWC2

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