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Pp2B-14D Protein phosphatase 2B at 14D [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32624, updated on 10-May-2024

Summary

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Official Symbol
Pp2B-14Dprovided by FlyBase
Official Full Name
Protein phosphatase 2B at 14Dprovided by FlyBase
Primary source
FLYBASE:FBgn0011826
Locus tag
Dmel_CG9842
See related
AllianceGenome:FB:FBgn0011826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
calneur; CaN; canA; CanA; CaNA; CanA14D; CG9842; CnA; CnnA14D; D33; Dmel\CG9842; DmPp2B-14D; Pp12-14D; Pp2B; PP2B; PP2B 14D; Pp2b-14D; PP2B-14D; Pp2B-14D/CaN; Pp2B-14DF; PpD33
Summary
Enables calmodulin-dependent protein phosphatase activity. Involved in several processes, including female meiotic nuclear division; sleep; and wing disc development. Predicted to be part of calcineurin complex. Predicted to be active in cytoplasm. Is expressed in adult head; central nervous system; organism; and presumptive embryonic/larval peripheral nervous system. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to several human genes including PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
14E1-14E3; 1-54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (16554627..16560016, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (16448660..16454049, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Actin-related protein 2 Neighboring gene Calcineurin A at 14F Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a cDNA encoding a Drosophila calcium/calmodulin regulated protein phosphatase, which has its most abundant expression in the early embryo. Brown L, et al. FEBS Lett, 1994 Feb 14. PMID 8313960
  2. Reduced Cardiac Calcineurin Expression Mimics Long-Term Hypoxia-Induced Heart Defects in Drosophila. Zarndt R, et al. Circ Cardiovasc Genet, 2017 Oct. PMID 28986453, Free PMC Article
  3. Calcineurin and its regulation by Sra/RCAN is required for completion of meiosis in Drosophila. Takeo S, et al. Dev Biol, 2010 Aug 15. PMID 20561515
  4. Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Schulz RA, et al. Dev Biol, 2004 Feb 1. PMID 14729474
  5. High-Amplitude Circadian Rhythms in Drosophila Driven by Calcineurin-Mediated Post-translational Control of sarah. Kweon SH, et al. Genetics, 2018 Jul. PMID 29724861, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium-dependent protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-dependent protein phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcineurin-mediated signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in female meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sleep IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of calcineurin complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein phosphatase 2B at 14D
Names
CG9842-PA
CG9842-PB
CG9842-PC
Pp2B-14D-PA
Pp2B-14D-PB
Pp2B-14D-PC
calcineurin
protein phosphatase D33
protein phosphatase from PCR fragment D33
NP_001245715.1
NP_001245716.1
NP_523373.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    16554627..16560016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258786.3 → NP_001245715.1  protein phosphatase 2B at 14D, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245715.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q26248, Q27889, Q9VXF2
    UniProtKB/TrEMBL
    M9NE01
    Conserved Domains (1) summary
    cd07416
    Location:107 → 411
    MPP_PP2B; PP2B, metallophosphatase domain

  2. NM_001258787.2 → NP_001245716.1  protein phosphatase 2B at 14D, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245716.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q26248, Q27889, Q9VXF2
    UniProtKB/TrEMBL
    M9NE01
    Conserved Domains (1) summary
    cd07416
    Location:107 → 411
    MPP_PP2B; PP2B, metallophosphatase domain

  3. NM_078649.4 → NP_523373.2  protein phosphatase 2B at 14D, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523373.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q26248, Q27889, Q9VXF2
    UniProtKB/TrEMBL
    M9NE01
    Related
    FBpp0074069
    Conserved Domains (1) summary
    cd07416
    Location:107 → 411
    MPP_PP2B; PP2B, metallophosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NE01 M9NE01
Q27889.2 Q27889
Q7JPT8 Q7JPT8

Gene LinkOut

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