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Prp5 pre-mRNA processing factor 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32464, updated on 18-Sep-2024

Summary

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Official Symbol
Prp5provided by FlyBase
Official Full Name
pre-mRNA processing factor 5provided by FlyBase
Primary source
FLYBASE:FBgn0030631
Locus tag
Dmel_CG6227
See related
AllianceGenome:FB:FBgn0030631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg6227; CG6227; Dmel\CG6227; DmRH29
Summary
Predicted to enable RNA helicase activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of spliceosomal complex. Predicted to be active in nucleus. Is expressed in adult head. Orthologous to human DDX46 (DEAD-box helicase 46). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
13B7-13B8; 1-50 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15345169..15350021)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15239202..15244054)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene abnormal chemosensory jump 6 Neighboring gene Protein phosphatase 1 at 13C Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recent strong positive selection on Drosophila melanogaster HDAC6, a gene encoding a stress surveillance factor, as revealed by population genomic analysis. Svetec N, et al. Mol Biol Evol, 2009 Jul. PMID 19349642
  2. Identification of novel Drosophila centromere-associated proteins. Barth TK, et al. Proteomics, 2014 Oct. PMID 24841622
  3. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
  4. Comprehensive analysis of nucleocytoplasmic dynamics of mRNA in Drosophila cells. Chen T, et al. PLoS Genet, 2017 Aug. PMID 28771467, Free PMC Article
  5. Changes in gene expression linked with adult reproductive diapause in a northern malt fly species: a candidate gene microarray study. Kankare M, et al. BMC Ecol, 2010 Feb 1. PMID 20122138, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
pre-mRNA processing factor 5
Names
CG6227-PA
Prp5-PA
NP_573020.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    15345169..15350021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132792.3 → NP_573020.2  pre-mRNA processing factor 5 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_573020.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5I7A3, C5I7B1, C5I7H5, Q9VXW2
    Related
    FBpp0073828
    Conserved Domains (3) summary
    COG0513
    Location:482 → 967
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00079
    Location:733 → 860
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:516 → 719
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95TU3 Q95TU3
Q9VXW2 Q9VXW2

Gene LinkOut

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